BPC-157 + TB-500 Blend
BPC-157 + TB-500 Blend

BPC-157 + TB-500 Blend

$35
BPC-157/TB-500 Blend: 10MG/10MG
117 pieces in stock

BPC-157 + TB-500 Blend Description

This is a blend (20mg) BPC-157 (10mg) and TB-500 (10mg).

BPC-157 (Body Protective Compound-157) is a stable gastrointestinal pentadecapeptide containing 15 amino acids, derived from gastric mucosal protective proteins. It promotes angiogenesis and collagen deposition by upregulating growth factors such as VEGF, accelerating repair of tendon, bone, nerve, and gastrointestinal injuries.
TB-500 is a 43-amino acid active fragment of thymosin β4. It enhances fibroblast and stem cell migration by regulating the actin cytoskeleton, induces angiogenesis, and suppresses inflammatory signaling, thereby improving muscle, myocardial, and skin wound healing.
The BPC-157/TB-500 Blend combines complementary pathways: the former primarily facilitates blood flow reconstruction and anti-inflammation, while the latter focuses on cell chemotaxis and matrix remodeling. In experimental models, it significantly shortens recovery times for ligament ruptures, muscle fiber tears, and post-surgical recovery, while enhancing the biomechanical strength of repaired tissues. 

Peptide Information

Specification BPC-157 GHK-Cu
Sequence Lys–Pro–Val Gly-His-Lys
Molecular Formula C₁₆H₃₀N₄O₄ C28H46CuN12O8
Molecular Weight 342.43 g/mol 744.3 g/mol
PubChem CID 125672 9831891
CAS Number 67727-97-3 130120-56-8
Synonyms ACTH(11-13), alpha-MSH(11-13) Thymosin-β4 fragment 17-23, TB-500 acetate, Ac-LKKTETQ


What is BPC-157?

BPC-157 (Body Protection Compound-157) is a naturally occurring bioactive peptide isolated and purified from human gastric mucosal protein extract. Composed of 15 amino acids, it constitutes an active fragment of endogenous gastroprotective peptides. Its stable structure exhibits resistance to gastric acid and enzymatic degradation. It maintains bioactivity not only through injection but also when administered orally, requiring no complex formulation modifications to exert its effects. It is currently one of the most extensively studied peptide molecules for tissue repair and protection.

BPC-157 promotes tissue regeneration and repair by activating fibroblast proliferation, accelerating collagen synthesis, and inducing angiogenesis to restore damaged connective tissues such as muscles, tendons, ligaments, and skin. It also modulates extracellular matrix metabolism to reduce scar tissue formation. It exhibits anti-inflammatory and immunomodulatory effects by suppressing pro-inflammatory factor release (e.g., TNF-α, IL-6), reducing inflammatory response intensity, and alleviating tissue edema and pain. It provides visceral protection, particularly offering potent defense for digestive mucosa (stomach, intestines) by enhancing mucosal barrier integrity and reducing damage from gastric acid or medications. It also protects organs like the liver and kidneys, mitigating oxidative stress and toxin-induced damage.

It can be used as an adjunct therapy for sports injuries such as tendinitis, muscle strains, and ligament tears, shortening recovery time and reducing the duration of impaired athletic performance. In gastrointestinal disease management, it addresses conditions like gastric ulcers, duodenal ulcers, and inflammatory bowel diseases (e.g., Crohn's disease) by protecting the mucosa, promoting mucosal repair, and alleviating abdominal pain and slow ulcer healing. In organ protection and repair research, it serves as an adjunctive intervention to mitigate drug-induced liver injury and chemical nephrotoxicity, while also demonstrating efficacy in repairing nerve damage (e.g., peripheral nerve contusions).

What is TB-500?

TB-500 (Thymosin Beta-4) is an endogenous peptide composed of 43 amino acids, derived from the core active region of naturally occurring human thymosin β4. It exhibits excellent water solubility and structural stability, naturally occurring widely in tissues like blood, muscle, and skin, and can be obtained through synthetic methods. Compared to intact thymosin β4, TB-500 retains key biological activity while being more readily absorbed by tissues via injection. It functions without requiring complex modifications, making it one of the most extensively studied peptide molecules in the field of tissue repair.

TB-500 promotes cell migration and tissue regeneration by activating the migratory capacity of repair-related cells such as endothelial cells and fibroblasts. It accelerates angiogenesis and collagen deposition, aiding in the repair of connective tissue injuries in muscles, tendons, ligaments, and skin. Simultaneously, it regulates extracellular matrix balance to reduce excessive scar formation. It exhibits anti-inflammatory and cytoprotective effects by inhibiting the release of pro-inflammatory factors like TNF-α and IL-1β, thereby reducing tissue inflammation and edema. Furthermore, it enhances cellular antioxidant stress resistance, mitigating damage from ischemia and toxins, and plays a crucial role in stabilizing the microenvironment of injured tissues.

It is used as an adjunct therapy for sports-related injuries such as muscle strains, tendinitis, and ligament tears, shortening the healing cycle and aiding in the restoration of athletic function. In wound healing, it accelerates closure of chronic non-healing wounds (e.g., diabetic foot ulcers) and burn injuries by promoting granulation tissue growth and epithelial cell migration. In tissue damage interventions, it also demonstrates efficacy in nerve injury (e.g., peripheral nerve contusion) and post-myocardial ischemia repair studies.

Conclusion

The BPC-157/TB-500 Blend is a composite system comprising two endogenous peptides with tissue repair activity. BPC-157, derived from human gastric mucosal protein, contains 15 amino acids, while TB-500 is an active fragment of thymosin β4, comprising 43 amino acids. When combined, they exert synergistic effects. BPC-157 promotes fibroblast proliferation, enhances mucosal barrier integrity, and suppresses pro-inflammatory factor release, while TB-500 regulates actin polymerization, accelerates cell migration, and stimulates angiogenesis. Together, they enhance tissue regeneration and repair efficiency, with additional anti-inflammatory effects, visceral organ protection, and improvement of the cellular microenvironment. Current application research focuses on sports injury recovery (e.g., tendinitis, muscle strains, ligament injuries); gastrointestinal mucosal protection (e.g., gastric ulcer, inflammatory bowel disease adjunctive intervention); and multi-tissue damage synergistic restoration (e.g., skin wounds, minor visceral injuries). This complementary mechanism shortens repair cycles, reduces inflammatory responses, and facilitates intervention in tissue damage-related issues.

For Research Use Only
This compound is provided exclusively for in vitro laboratory research. It is not intended for human or animal consumption, diagnosis, treatment, or medical use. Not for dietary, cosmetic, or veterinary purposes. This product has not been evaluated by the U.S. Food and Drug Administration or any other regulatory authority.

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The products provided on this website are intended exclusively for in vitro research. In vitro research (Latin: *in glass*, meaning in glassware) is conducted outside the human body. These products are not pharmaceuticals, have not been approved by the U.S. Food and Drug Administration (FDA), and must not be used to prevent, treat, or cure any medical condition, disease, or ailment. It is strictly prohibited by law to introduce these products into the human or animal body in any form.

Polypeptide Purity Control and Verification Technical System

Humatide.com provides peptides with purity exceeding 99%. Humatide achieves precise control and scientific verification of polypeptide purity by integrating advanced technologies and a full-process quality control system: In the synthesis stage, automated solid-phase peptide synthesis (SPPS) is employed to accurately assemble amino acid sequences. A gradient purification strategy ranging from medium-pressure liquid chromatography (MPLC) to preparative high-performance liquid chromatography (Prep-HPLC) is utilized, optimizing mobile phase composition and elution conditions based on the physicochemical properties of the target peptide (hydrophobicity, charge distribution, etc.) to efficiently remove impurities. For purity detection, reverse-phase high-performance liquid chromatography (RP-HPLC) serves as the core technique, separating components through the distribution difference of molecules between the stationary phase (hydrophobic packing) and the mobile phase (polar solvent). Purity is determined via retention time matching and peak area normalization. Meanwhile, electrospray ionization mass spectrometry (ESI-MS) is combined to precisely verify the molecular weight and composition through mass-to-charge ratio (m/z) analysis, eliminating structurally heterogeneous impurities. Quality management covers the entire chain from raw material acceptance, synthesis process monitoring to finished product release. A continuous quality fingerprint is constructed using multi-dimensional indicators (HPLC purity, MS molecular weight, solvent residue, etc.), and batch data traceability is achieved through a laboratory information management system (LIMS), ensuring each batch meets the prespecified purity standards. This system provides a reliable technical guarantee for preparing high-purity polypeptides through the organic integration of process optimization, multi-dimensional detection, and full-process quality control.

Concepts of High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS)

High-performance liquid chromatography (HPLC) is a separation technology widely used by Humatide for peptide purification. Driven by a high-pressure pump, the mobile phase carries samples through a chromatographic column packed with a specific stationary phase, achieving separation based on differences in the distribution coefficients of components between the two phases. It features high separation efficiency, fast analysis speed, and strong detection sensitivity, enabling precise capture of subtle differences between target peptides and impurities such as sequence analogs or deletion peptides.

Mass spectrometry (MS) is an analytical method that converts peptide molecules into gas-phase ions through ionization technology and separates/detects ions based on their mass-to-charge ratio (m/z). It can accurately determine the molecular weight of peptides and infer amino acid sequences through fragment ion information, serving as a key technology for verifying peptide structural correctness. The combination of these two techniques allows Humatide to establish a complete quality control system from both purity separation and structural confirmation perspectives. Both methods are high-precision peptide detection technologies that scientifically demonstrate the purity and composition of peptides ordered from Humatide.com.

Humatide is committed to translating cutting-edge analytical technologies into tangible quality assurance. Our peptide synthesis laboratories are equipped with high-resolution mass spectrometers and ultra-high-performance liquid chromatography systems. Through real-time detection and data comparison of samples at each production stage, we continuously optimize synthesis processes to ensure every peptide product is delivered to customers with exceptional purity.

Recommended Peptide Purity Levels

Humatide provides only the highest-purity peptides (purity ≥99%) for research and development. The minimum recommended peptide purity level for specific applications depends on the application:

• In biochemical research, peptides used for enzyme activity analysis typically require ≥85% purity.

• In drug development, peptides for preclinical trials must meet >98% high-purity standards to ensure biological activity and safety.

• For diagnostic applications (e.g., antigen peptides in immunoassays), recommended purity is 90%-95% to guarantee detection specificity and sensitivity.

Humatide is confident in the quality of all our products, implementing strict quality monitoring at every stage of peptide synthesis—from crude peptide purification to final product release. Through multi-step purification and verification processes, we ensure each batch meets or exceeds the purity requirements for specific applications. Examples of acceptable minimum purity levels are as follows:

High Purity (>95%)

• Polypeptide drug research and production

• Preparation of targeted therapeutic drugs

• Raw materials for biological diagnostic reagents (e.g., ELISA, immunoassay kits)

• Development of polypeptide vaccines (therapeutic/preventive)

• Preparation of targeting peptides for antibody-drug conjugates (ADCs)

• Polypeptide reagents for life science research (e.g., receptor agonists/antagonists)

• Research on targeting peptide modification for gene therapy vectors

• Development of polypeptide antibiotics/antimicrobial peptides

• Preparation of polypeptide hormone analogs (e.g., insulin analogs)

• Reference standards for biomarker detection

• Research on cell culture additives

• Synthetic peptides for protein structure analysis and functional studies

Moderate Purity (>85%)

• Early-stage activity screening in polypeptide drug research

• Peptide additives for industrial enzymes

• Signal peptide raw materials

• Surface modification of biomaterials (e.g., medical catheters, tissue engineering scaffolds)

• Preparation of agricultural antimicrobial peptides

• Cell adhesion research

• Raw materials for polypeptide surfactants/detergents

• Polypeptide reagents for preliminary mechanistic research in scientific studies

Lower Purity (>70%)

• Preliminary structure-activity relationship (SAR) studies

• Initial verification of protein binding

• Primary cytotoxicity screening

• High-throughput screening of polypeptide drug lead compounds


Please note

**We are not responsible for reconstitution or any issue that arise from it**


High-purity polypeptides are suitable for scenarios requiring strict purity. The ultra-high-purity peptides provided by Humatide can meet and exceed all prespecified purity standards.

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BPC-157 + TB-500 Blend
BPC-157 + TB-500 Blend
10MG/10MG
$35

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