KLOW Blend
KLOW Blend

KLOW Blend

$60
KLOW: 80MG

BPC-157 + TB-500 + KPV + GHK-Cu Blend Description

This is a blend (80mg) each of BPC-157 (10mg) + TB-500 (10mg) + KPV (10mg) + GHK-Cu (50mg).

Klow is a blend comprising TB4, BPC-157, KPV, and GHK-CU. TB4(TB-500) modulates actin dynamics to promote cell migration, angiogenesis, and collagen synthesis, supporting connective tissue regeneration; BPC-157 upregulates relevant factor expression, enhances angiogenesis and fibroblast activity, repairs multiple tissues, and provides cellular protection; KPV suppresses pro-inflammatory factors, reduces inflammation, and promotes mucosal repair; GHK-Cu stimulates collagen production, regulates inflammation and antioxidant activity, and supports tissue repair. The four peptides complement each other: TB500 and BPC-157 provide migration-angiogenesis-matrix templating, KPV blocks inflammatory negative feedback, while GHK-Cu stabilizes collagen cross-linking and scavenges free radicals. This forms an “anti-inflammatory-migration-regeneration-remodeling” closed loop, enabling Klow to significantly accelerate repair, reduce scarring, and restore function in soft tissue injuries, postoperative healing, skin aging, and mucosal ulcers..

Peptide Information

Specification BPC-157 GHK-Cu
Sequence Lys–Pro–Val Gly-His-Lys
Molecular Formula C₁₆H₃₀N₄O₄ C28H46CuN12O8
Molecular Weight 342.43 g/mol 744.3 g/mol
PubChem CID 125672 9831891
CAS Number 67727-97-3 130120-56-8
Synonyms ACTH(11-13), alpha-MSH(11-13) Thymosin-β4 fragment 17-23, TB-500 acetate, Ac-LKKTETQ

 

Specification KPV GHK-Cu
Sequence Lys–Pro–Val Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ)
Molecular Formula C₆₂H₉₈N₁₆O₂₂ C₃₈H₆₈N₁₂O₁₄
Molecular Weight 1419.5 g/mol 889.0 g/mol
PubChem CID 9941957 62707662
CAS Number 137525-51-0 885340-08-9
Synonyms PL-14736, Body-Protection Compound-157, Bepecin Bisprezatide copper；DL1TR6W6VM

 

What is TB4(TB-500)?

TB4 is a synthetic peptide composed of 43 amino acids. Its sequence exhibits high homology with the active fragment of thymosin β4 (Tβ4), a multifunctional peptide naturally present in the human body that extensively participates in physiological processes such as cellular repair and inflammation regulation. The core mechanism of TB4 involves binding to actin on the cell surface to regulate cytoskeletal reorganization, thereby significantly promoting cell migration and tissue regeneration. In muscle, tendon, or ligament injury models, TB4 accelerates the aggregation of fibroblasts at the injury site, promotes the orderly arrangement of collagen fibers, shortens the healing cycle, and reduces the likelihood of scar tissue formation. TB4 induces angiogenesis by stimulating cytokine expression (e.g., vascular endothelial growth factor, VEGF), improving blood perfusion in injured areas to deliver ample oxygen and nutrients for tissue repair. It inhibits pro-inflammatory factor release (e.g., TNF-α, IL-6) and modulates macrophage polarization, thereby reducing post-injury inflammatory responses at the immunoregulatory level and preventing tissue damage from excessive inflammation.

What is BPC-157?

BPC-157 is a synthetic peptide composed of 15 amino acids. Its sequence originates from the Body Protection Compound (BPC) fragment within human gastric mucosal proteins, serving as an artificial analog of endogenous gastrointestinal protective peptides. The core biological characteristic of this peptide lies in its potent tissue repair regulatory capacity. It promotes proliferation and migration of repair-related cells like fibroblasts and endothelial cells by activating tyrosine kinase receptors (e.g., c-Met), while accelerating synthesis and remodeling of extracellular matrix components (e.g., collagen, fibronectin). This effect has been validated in models of gastrointestinal ulcers, tendon ruptures, and bone defects. In gastric mucosal injury models, BPC 157 significantly shortens ulcer healing time and improves mucosal regeneration quality.

BPC 157 exerts a key role by modulating the inflammatory microenvironment. It suppresses neutrophil infiltration and the overexpression of pro-inflammatory factors (such as IL-1β and NF-κB), while simultaneously upregulating the secretion of anti-inflammatory factors (such as IL-10). This mitigates the acute inflammatory response following injury and prevents secondary tissue damage caused by uncontrolled inflammation. Its vasoprotective effects are particularly pronounced. By stimulating the release of vascular endothelial growth factor (VEGF) and angiopoietin, it promotes the formation of a new vascular network in damaged areas, improves local blood perfusion, and provides adequate nutrient and oxygen supply for tissue repair.

What is KPV?

KPV, a tripeptide composed of lysine-proline-valine, originates from the C-terminal region of α-melanocyte-stimulating hormone (α-MSH) and is a naturally occurring fragment with significant biological activity.

In inflammation regulation, KPV exhibits potent anti-inflammatory activity. It effectively suppresses the nuclear factor-κB (NF-κB) signaling pathway, reducing the transcription and release of pro-inflammatory cytokines (such as IL-1β, TNF-α, etc.), thereby curbing inflammatory cascades at their source. In animal models of colitis, oral administration of KPV significantly reduces intestinal inflammation levels and alleviates mucosal damage. This effect stems from its precise regulation of inflammatory signaling in intestinal immune cells and epithelial cells. KPV further mitigates local inflammatory responses by stabilizing mast cells and reducing the release of inflammatory mediators like histamine, thereby maintaining tissue homeostasis.

At the immunoregulatory level, KPV demonstrates bidirectional modulation capabilities. It enhances T-cell differentiation and function, promotes the secretion of immunoregulatory factors like IL-2 and IFN-γ, and boosts cellular immune responses. In autoimmune disease models, KPV regulates Th1/Th2 cell balance, reduces excessive autoimmune reactions, and prevents immune damage.

KPV also holds potential value in cellular proliferation and tissue repair. By activating relevant intracellular signaling pathways, it promotes fibroblast proliferation and migration, accelerates the synthesis of extracellular matrix components like collagen, and facilitates wound healing in tissues such as skin and muscle. In skin repair experiments, KPV-treated wounds exhibited significantly accelerated healing rates and reduced scar formation, demonstrating its positive impact on tissue repair quality. KPV may also stimulate the expression of angiogenesis-related factors like vascular endothelial growth factor (VEGF), promoting neovascularization and improving blood supply to injured sites, thereby providing essential conditions for tissue regeneration.

What is GHK-Cu?

GHK-Cu is a complex formed by glycyl-L-histidyl-L-lysine tripeptide and copper ions. Leveraging the synergistic action of copper ions and the tripeptide, it performs multiple critical functions in physiological activities. In skin repair and regeneration, it acts as a signaling peptide to induce fibroblasts to synthesize collagen, elastin, and glycosaminoglycans, enhancing skin firmness and elasticity while improving skin issues caused by aging or photoaging. During wound healing, it stimulates stratum corneum cell growth to accelerate closure while regulating inflammation by suppressing excessive IL-6 and TNF-α expression. It also promotes macrophage aggregation to release growth factors, aiding tissue repair and remodeling. Its potent antioxidant and anti-inflammatory properties regulate intracellular copper levels, enhance antioxidant capacity, and delay cellular aging. In pulmonary inflammation models, it mitigates lipopolysaccharide-induced acute lung injury and improves tissue inflammatory states. GHK-Cu benefits hair health by stimulating hair follicle cell activity, promoting melanin production, regulating energy metabolism, and aiding in hair loss improvement.

Conclusion

As a blend of TB 500, BPC-157, KPV, and GHK-Cu, Klow's synergistic effects manifest through the overlapping and complementary regulation of multidimensional physiological functions. TB 500 promotes cell migration and angiogenesis, BPC-157 enhances tissue repair and inflammatory regulation, KPV focuses on immune balance and local anti-inflammation, while GHK-Cu functions in antioxidant defense, skin regeneration, and microenvironment optimization. Together, they form a closed-loop system of “repair-anti-inflammation-immune modulation-microenvironment enhancement.”

Under this synergy, TB 500 and BPC-157 accelerate cell proliferation and matrix synthesis, while KPV mitigates excessive inflammation by inhibiting the NF-κB pathway, creating a stable environment for repair. GHK-Cu's antioxidant properties reduce free radical damage to newly formed tissues, and its vasoprotective effects synergize with TB 500's angiogenesis function to enhance local blood supply. KPV's bidirectional immune modulation balances the immune activation triggered by BPC-157 and GHK-Cu, preventing immune dysregulation. This synergy not only shortens tissue repair cycles but also improves repair quality and reduces scar formation risk, offering comprehensive regulatory advantages in scenarios such as wound healing, chronic inflammation, and skin aging.

For Research Use Only
This compound is provided exclusively for in vitro laboratory research. It is not intended for human or animal consumption, diagnosis, treatment, or medical use. Not for dietary, cosmetic, or veterinary purposes. This product has not been evaluated by the U.S. Food and Drug Administration or any other regulatory authority.

Disclaimer
All information is for educational purposes only. Humatide makes no claims regarding efficacy or safety. Purchasers are responsible for ensuring proper handling and use in compliance with all applicable laws and regulations.

Terms of Sale
By purchasing from Humatide, you confirm that you are a qualified researcher with the knowledge and facilities to safely handle and store research chemicals. All sales are final. Humatide assumes no liability for misuse, misrepresentation, or unintended consequences arising from the use of this product.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE SOLELY FOR INFORMATION DISSEMINATION AND EDUCATIONAL PURPOSES.

The products provided on this website are intended exclusively for in vitro research. In vitro research (Latin: *in glass*, meaning in glassware) is conducted outside the human body. These products are not pharmaceuticals, have not been approved by the U.S. Food and Drug Administration (FDA), and must not be used to prevent, treat, or cure any medical condition, disease, or ailment. It is strictly prohibited by law to introduce these products into the human or animal body in any form.

Polypeptide Purity Control and Verification Technical System

Humatide.com provides peptides with purity exceeding 99%. Humatide achieves precise control and scientific verification of polypeptide purity by integrating advanced technologies and a full-process quality control system: In the synthesis stage, automated solid-phase peptide synthesis (SPPS) is employed to accurately assemble amino acid sequences. A gradient purification strategy ranging from medium-pressure liquid chromatography (MPLC) to preparative high-performance liquid chromatography (Prep-HPLC) is utilized, optimizing mobile phase composition and elution conditions based on the physicochemical properties of the target peptide (hydrophobicity, charge distribution, etc.) to efficiently remove impurities. For purity detection, reverse-phase high-performance liquid chromatography (RP-HPLC) serves as the core technique, separating components through the distribution difference of molecules between the stationary phase (hydrophobic packing) and the mobile phase (polar solvent). Purity is determined via retention time matching and peak area normalization. Meanwhile, electrospray ionization mass spectrometry (ESI-MS) is combined to precisely verify the molecular weight and composition through mass-to-charge ratio (m/z) analysis, eliminating structurally heterogeneous impurities. Quality management covers the entire chain from raw material acceptance, synthesis process monitoring to finished product release. A continuous quality fingerprint is constructed using multi-dimensional indicators (HPLC purity, MS molecular weight, solvent residue, etc.), and batch data traceability is achieved through a laboratory information management system (LIMS), ensuring each batch meets the prespecified purity standards. This system provides a reliable technical guarantee for preparing high-purity polypeptides through the organic integration of process optimization, multi-dimensional detection, and full-process quality control.

Concepts of High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS)

High-performance liquid chromatography (HPLC) is a separation technology widely used by Humatide for peptide purification. Driven by a high-pressure pump, the mobile phase carries samples through a chromatographic column packed with a specific stationary phase, achieving separation based on differences in the distribution coefficients of components between the two phases. It features high separation efficiency, fast analysis speed, and strong detection sensitivity, enabling precise capture of subtle differences between target peptides and impurities such as sequence analogs or deletion peptides.

Mass spectrometry (MS) is an analytical method that converts peptide molecules into gas-phase ions through ionization technology and separates/detects ions based on their mass-to-charge ratio (m/z). It can accurately determine the molecular weight of peptides and infer amino acid sequences through fragment ion information, serving as a key technology for verifying peptide structural correctness. The combination of these two techniques allows Humatide to establish a complete quality control system from both purity separation and structural confirmation perspectives. Both methods are high-precision peptide detection technologies that scientifically demonstrate the purity and composition of peptides ordered from Humatide.com.

Humatide is committed to translating cutting-edge analytical technologies into tangible quality assurance. Our peptide synthesis laboratories are equipped with high-resolution mass spectrometers and ultra-high-performance liquid chromatography systems. Through real-time detection and data comparison of samples at each production stage, we continuously optimize synthesis processes to ensure every peptide product is delivered to customers with exceptional purity.

Recommended Peptide Purity Levels

Humatide provides only the highest-purity peptides (purity ≥99%) for research and development. The minimum recommended peptide purity level for specific applications depends on the application:

• In biochemical research, peptides used for enzyme activity analysis typically require ≥85% purity.

• In drug development, peptides for preclinical trials must meet >98% high-purity standards to ensure biological activity and safety.

• For diagnostic applications (e.g., antigen peptides in immunoassays), recommended purity is 90%-95% to guarantee detection specificity and sensitivity.

Humatide is confident in the quality of all our products, implementing strict quality monitoring at every stage of peptide synthesis—from crude peptide purification to final product release. Through multi-step purification and verification processes, we ensure each batch meets or exceeds the purity requirements for specific applications. Examples of acceptable minimum purity levels are as follows:

High Purity (>95%)

• Polypeptide drug research and production

• Preparation of targeted therapeutic drugs

• Raw materials for biological diagnostic reagents (e.g., ELISA, immunoassay kits)

• Development of polypeptide vaccines (therapeutic/preventive)

• Preparation of targeting peptides for antibody-drug conjugates (ADCs)

• Polypeptide reagents for life science research (e.g., receptor agonists/antagonists)

• Research on targeting peptide modification for gene therapy vectors

• Development of polypeptide antibiotics/antimicrobial peptides

• Preparation of polypeptide hormone analogs (e.g., insulin analogs)

• Reference standards for biomarker detection

• Research on cell culture additives

• Synthetic peptides for protein structure analysis and functional studies

Moderate Purity (>85%)

• Early-stage activity screening in polypeptide drug research

• Peptide additives for industrial enzymes

• Signal peptide raw materials

• Surface modification of biomaterials (e.g., medical catheters, tissue engineering scaffolds)

• Preparation of agricultural antimicrobial peptides

• Cell adhesion research

• Raw materials for polypeptide surfactants/detergents

• Polypeptide reagents for preliminary mechanistic research in scientific studies

Lower Purity (>70%)

• Preliminary structure-activity relationship (SAR) studies

• Initial verification of protein binding

• Primary cytotoxicity screening

• High-throughput screening of polypeptide drug lead compounds


Please note

**We are not responsible for reconstitution or any issue that arise from it**


High-purity polypeptides are suitable for scenarios requiring strict purity. The ultra-high-purity peptides provided by Humatide can meet and exceed all prespecified purity standards.

Humatide Shipping & Delivery

Shipping Methods & Delivery Times

Standard handling is 24 hours excluding Holidays and Weekends

International Shipping – Not available at this time.

The explained transit time are not guaranteed.  Humatide is not responsible nor will refunds be given due to transit delays.

Order Tracking

Once your order has shipped, you’ll receive an email with a tracking number and link.
If you experience any tracking issues, reach out to us at help@humatide.com.

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Carrier Delays

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Returns & Exchanges

Refund Policy
Due to the sensitive nature of research products, all sales are final.
We cannot accept returns or issue refunds once an order has been shipped. This policy helps ensure product integrity and safety for all of our research partners.

Damaged or Defective Items

If your order is damaged and you declined shipping protection we can only provide you with up to $100 in store credit.  If you did select shipment protection we will replace any damaged good and ship out replacements at no cost.  If your order is incorrect, or missing items, please contact us within 48 hours of delivery so we can resolve the issue.  Please provide photos of the damaged items.

Lost or Stolen Shipments

If your order is lost or stolen and you declined shipping protection the maximum credit we can give you is $100 in store credit.  If you did select shipment protection we will replace the entire order if it's been lost at no charge if it is lost or stolen.  Please contact us within 48 hours of delivery so we can work with UPS to help resolve the issue.  

Final Sale Items

All sales are final and products are not eligible for return or exchange. 

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Contact our support team anytime at help@humatide.com with any questions about shipping or returns.

To View the latest Certificate of Analysis (CoA) click the "View Latest 3rd Party Certificate of Analysis" button on the product page.  Please use that if you are looking to buy as that is the batch you'll receive if you place an order.  The QRCode will give you the Batch ID/Lot Number which is matched on the CoA to validate that CoA matches your specific vial.  If you happen to get a vial that is from a previous batch select the "Previous Batch 3rd Party Certificate of Analysis" if your Batch ID doesn't match the latest CoA.   

All CoA are searchable via the respective testers' website. 

ILS Labs Verification is available on their website at:  

https://ils-lab.com/verify

To validate the CoA on the ILS Labs website enter the Access Code that is located on the bottom of the CoA that is shown on our website.   

We also use MDx Biolabs, verification is available via their website at:  

https://mdxbiolabs.com/certificates-of-analysis

To find validate the CoA on the MDx Biolabs website enter the COA number which is located at the bottom of the CoA that is shown on our website.  

 

 

 

KLOW Blend
KLOW Blend
80MG
$60

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