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AOD-9604
NOTE: Reconstitution must be done with Acetic Acid.
AOD-9604 Description
AOD-9604 is a research peptide consisting of amino acids 177–191 of the human growth hormone sequence. Studies indicate it modulates lipid and glucose metabolism pathways without influencing IGF-1 activity, acting primarily through β-adrenergic and AMPK-related mechanisms. It is commonly used in metabolic and adipocyte differentiation research to elucidate downstream energy regulation signaling.
Peptide Information
| Property | Value |
|---|---|
| Peptide Sequence | H-Tyr-Leu-Arg-Ile-Val-Gln-Cys(1)-Arg-Ser-Val-Glu-Gly-Ser-Cys(1)-Gly-Phe-OH |
| Molecular Formula | C78H123N23O23S2 |
| Molecular Weight | 1815.1 g/mol |
| CAS Number | 221231-10-3 |
| PubChem CID | 71300630 |
| Synonyms | AOD-9604, AOD 9604 |
AOD9604 Research
1. AOD9604 and Obesity
This peptide was originally created as a modified growth hormone fragment with the primary goal of assisting weight management. In mid-stage clinical work involving a sizeable group of adults with obesity, once-daily dosing over several weeks produced greater average weight reduction compared to placebo, and the pace of weight loss remained steady throughout the observation period. These findings suggest that the body does not quickly adapt to or resist its effects, raising the possibility that extended use under appropriate conditions could lead to more substantial fat loss.
2. Joint Pain and Function
Preclinical research in animals with experimentally induced joint degeneration has shown that injecting AOD9604 directly into affected joints can complement existing treatments. In these models, the peptide has been associated with reduced pain-related behaviors, improved mobility, and measurable changes in cartilage structure that are consistent with healthier joint tissue. Although it appears to have beneficial effects on its own, outcomes are often better when AOD9604 is combined with other joint-supporting therapies, suggesting a synergistic potential and pointing to new avenues for exploring cartilage repair strategies.
3. AOD9604 and Heart Health
While reducing excess fat and body weight is known to lower cardiovascular risk, investigations suggest that AOD9604 may have additional influences on metabolic processes that are relevant to heart health. Some findings indicate that it could improve certain metabolic markers independently of its role in fat loss, similar to how other compounds can modify metabolic risk factors without necessarily causing weight reduction. The alternative pathways through which AOD9604 promotes changes in fat tissue, beyond beta-3 adrenergic receptor activity, are of particular interest for their potential impact on broader metabolic balance.
In animal testing, AOD9604 has generally shown a favorable tolerability profile, with good absorption when given orally and effective uptake when administered by injection. Dosages used in animal experiments cannot be directly translated to appropriate amounts for human use. This compound is intended strictly for controlled laboratory and scientific research and is not approved for human consumption or therapeutic application.
For Research Use Only
This compound is provided exclusively for in vitro laboratory research. It is not intended for human or animal consumption, diagnosis, treatment, or medical use. Not for dietary, cosmetic, or veterinary purposes. This product has not been evaluated by the U.S. Food and Drug Administration or any other regulatory authority.
Disclaimer
All information is for educational purposes only. Humatide makes no claims regarding efficacy or safety. Purchasers are responsible for ensuring proper handling and use in compliance with all applicable laws and regulations.
Terms of Sale
By purchasing from Humatide, you confirm that you are a qualified researcher with the knowledge and facilities to safely handle and store research chemicals. All sales are final. Humatide assumes no liability for misuse, misrepresentation, or unintended consequences arising from the use of this product.
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE SOLELY FOR INFORMATION DISSEMINATION AND EDUCATIONAL PURPOSES.
The products provided on this website are intended exclusively for in vitro research. In vitro research (Latin: *in glass*, meaning in glassware) is conducted outside the human body. These products are not pharmaceuticals, have not been approved by the U.S. Food and Drug Administration (FDA), and must not be used to prevent, treat, or cure any medical condition, disease, or ailment. It is strictly prohibited by law to introduce these products into the human or animal body in any form.
Polypeptide Purity Control and Verification Technical System
Humatide.com provides peptides with purity exceeding 99%. Humatide achieves precise control and scientific verification of polypeptide purity by integrating advanced technologies and a full-process quality control system: In the synthesis stage, automated solid-phase peptide synthesis (SPPS) is employed to accurately assemble amino acid sequences. A gradient purification strategy ranging from medium-pressure liquid chromatography (MPLC) to preparative high-performance liquid chromatography (Prep-HPLC) is utilized, optimizing mobile phase composition and elution conditions based on the physicochemical properties of the target peptide (hydrophobicity, charge distribution, etc.) to efficiently remove impurities. For purity detection, reverse-phase high-performance liquid chromatography (RP-HPLC) serves as the core technique, separating components through the distribution difference of molecules between the stationary phase (hydrophobic packing) and the mobile phase (polar solvent). Purity is determined via retention time matching and peak area normalization. Meanwhile, electrospray ionization mass spectrometry (ESI-MS) is combined to precisely verify the molecular weight and composition through mass-to-charge ratio (m/z) analysis, eliminating structurally heterogeneous impurities. Quality management covers the entire chain from raw material acceptance, synthesis process monitoring to finished product release. A continuous quality fingerprint is constructed using multi-dimensional indicators (HPLC purity, MS molecular weight, solvent residue, etc.), and batch data traceability is achieved through a laboratory information management system (LIMS), ensuring each batch meets the prespecified purity standards. This system provides a reliable technical guarantee for preparing high-purity polypeptides through the organic integration of process optimization, multi-dimensional detection, and full-process quality control.
Concepts of High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS)
High-performance liquid chromatography (HPLC) is a separation technology widely used by Humatide for peptide purification. Driven by a high-pressure pump, the mobile phase carries samples through a chromatographic column packed with a specific stationary phase, achieving separation based on differences in the distribution coefficients of components between the two phases. It features high separation efficiency, fast analysis speed, and strong detection sensitivity, enabling precise capture of subtle differences between target peptides and impurities such as sequence analogs or deletion peptides.
Mass spectrometry (MS) is an analytical method that converts peptide molecules into gas-phase ions through ionization technology and separates/detects ions based on their mass-to-charge ratio (m/z). It can accurately determine the molecular weight of peptides and infer amino acid sequences through fragment ion information, serving as a key technology for verifying peptide structural correctness. The combination of these two techniques allows Humatide to establish a complete quality control system from both purity separation and structural confirmation perspectives. Both methods are high-precision peptide detection technologies that scientifically demonstrate the purity and composition of peptides ordered from Humatide.com.
Humatide is committed to translating cutting-edge analytical technologies into tangible quality assurance. Our peptide synthesis laboratories are equipped with high-resolution mass spectrometers and ultra-high-performance liquid chromatography systems. Through real-time detection and data comparison of samples at each production stage, we continuously optimize synthesis processes to ensure every peptide product is delivered to customers with exceptional purity.
Recommended Peptide Purity Levels
Humatide provides only the highest-purity peptides (purity ≥99%) for research and development. The minimum recommended peptide purity level for specific applications depends on the application:
• In biochemical research, peptides used for enzyme activity analysis typically require ≥85% purity.
• In drug development, peptides for preclinical trials must meet >98% high-purity standards to ensure biological activity and safety.
• For diagnostic applications (e.g., antigen peptides in immunoassays), recommended purity is 90%-95% to guarantee detection specificity and sensitivity.
Humatide is confident in the quality of all our products, implementing strict quality monitoring at every stage of peptide synthesis—from crude peptide purification to final product release. Through multi-step purification and verification processes, we ensure each batch meets or exceeds the purity requirements for specific applications. Examples of acceptable minimum purity levels are as follows:
High Purity (>95%)
• Polypeptide drug research and production
• Preparation of targeted therapeutic drugs
• Raw materials for biological diagnostic reagents (e.g., ELISA, immunoassay kits)
• Development of polypeptide vaccines (therapeutic/preventive)
• Preparation of targeting peptides for antibody-drug conjugates (ADCs)
• Polypeptide reagents for life science research (e.g., receptor agonists/antagonists)
• Research on targeting peptide modification for gene therapy vectors
• Development of polypeptide antibiotics/antimicrobial peptides
• Preparation of polypeptide hormone analogs (e.g., insulin analogs)
• Reference standards for biomarker detection
• Research on cell culture additives
• Synthetic peptides for protein structure analysis and functional studies
Moderate Purity (>85%)
• Early-stage activity screening in polypeptide drug research
• Peptide additives for industrial enzymes
• Signal peptide raw materials
• Surface modification of biomaterials (e.g., medical catheters, tissue engineering scaffolds)
• Preparation of agricultural antimicrobial peptides
• Cell adhesion research
• Raw materials for polypeptide surfactants/detergents
• Polypeptide reagents for preliminary mechanistic research in scientific studies
Lower Purity (>70%)
• Preliminary structure-activity relationship (SAR) studies
• Initial verification of protein binding
• Primary cytotoxicity screening
• High-throughput screening of polypeptide drug lead compounds
Please note
**We are not responsible for reconstitution or any issue that arise from it**
High-purity polypeptides are suitable for scenarios requiring strict purity. The ultra-high-purity peptides provided by Humatide can meet and exceed all prespecified purity standards.
Humatide Shipping & Delivery
Shipping Methods & Delivery Times
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International Shipping – Not available at this time.
The explained transit time are not guaranteed. Humatide is not responsible nor will refunds be given due to transit delays.
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Address Accuracy
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Returns & Exchanges
Refund Policy
Due to the sensitive nature of research products, all sales are final.
We cannot accept returns or issue refunds once an order has been shipped. This policy helps ensure product integrity and safety for all of our research partners.
Damaged or Defective Items
If your order is damaged and you declined shipping protection we can only provide you with up to $100 in store credit. If you did select shipment protection we will replace any damaged good and ship out replacements at no cost. If your order is incorrect, or missing items, please contact us within 48 hours of delivery so we can resolve the issue. Please provide photos of the damaged items.
Lost or Stolen Shipments
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Final Sale Items
All sales are final and products are not eligible for return or exchange.
Need Help?
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To View the latest Certificate of Analysis (CoA) click the "View Latest 3rd Party Certificate of Analysis" button on the product page. Please use that if you are looking to buy as that is the batch you'll receive if you place an order. The QRCode will give you the Batch ID/Lot Number which is matched on the CoA to validate that CoA matches your specific vial. If you happen to get a vial that is from a previous batch select the "Previous Batch 3rd Party Certificate of Analysis" if your Batch ID doesn't match the latest CoA.
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We also use MDx Biolabs, verification is available via their website at:
https://mdxbiolabs.com/certificates-of-analysis
To find validate the CoA on the MDx Biolabs website enter the COA number which is located at the bottom of the CoA that is shown on our website.
AOD-9604
10MG
$40
