{"product_id":"tb-500-500mcg-120-capsules","title":"TB-500 Capsules","description":"\u003ch2\u003e\u003cstrong\u003eTB-500 Description\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003eTB500, a synthetic analog of Thymosin Beta-4 (Tβ4), promotes tissue repair and regeneration by regulating actin dynamics and stimulating cell migration, proliferation, and differentiation.TB500 is a functional fragment of thymosin β4 primarily used to study mechanisms related to cell migration and tissue repair. Its actions focus on promoting cell motility, supporting tissue structural reconstruction, and participating in repair signal regulation. Research indicates that TB500 is closely associated with cytoskeletal regulation, particularly influencing actin dynamics. Its mechanism enhances the coordination of tissue repair processes by modulating cell migration-related signaling pathways. TB500 holds significant research value in the fields of tissue regeneration, injury repair, and cell migration studies. \u003cbr\u003e  \u003c\/p\u003e\n\u003ch3 class=\"text-lg font-bold text-text-100 mt-1 -mb-1.5\"\u003ePeptide Information\u003c\/h3\u003e\n\u003ctable class=\"bg-bg-100 min-w-full border-separate border-spacing-0 text-sm leading-[1.88888] whitespace-normal\" style=\"width: 100%; height: 138.867px;\"\u003e\n\u003cthead class=\"border-b-border-100\/50 border-b-[0.5px] text-left\"\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003cth class=\"text-text-000 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003eProperty\u003c\/th\u003e\n\u003cth class=\"text-text-000 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003eValue\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003ePeptide Sequence\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003e\n\u003cdiv class=\"text-left sm:table-cell sm:p-2 sm:border-t sm:border-gray-300 dark:sm:border-gray-300\/20 pb-1 pl-2 sm:align-middle\"\u003e\n\u003cdiv class=\"break-words space-y-1\"\u003eAc-Leu-Lys-Lys-Thr-Glu-Thr-Gln-OH\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 21.2667px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 21.2667px;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 21.2667px;\"\u003eC\u003csub\u003e38\u003c\/sub\u003eH\u003csub\u003e68\u003c\/sub\u003eN\u003csub\u003e10\u003c\/sub\u003eO\u003csub\u003e14\u003c\/sub\u003e\u003csub\u003e\u003c\/sub\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003e889.0 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003e885340-08-9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003e62707662\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eQHK6Z47GTG\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"tab-content active\" id=\"tab-description\"\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cdiv id=\"prod_describe_new_2\" class=\"prod_describe_new3\"\u003e\n\u003cdiv class=\"prod_describe_new_content\"\u003e\n\u003cdiv class=\"prodDetail-editor-container sliderTable\"\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong style=\"font-size: 24px;\"\u003eTB500 Research\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003eWhat is the research background of TB500?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eTB500 is a small peptide processed from the active site of thymosin β4. Thymosin β4 has the abilities of tissue regeneration, anti-inflammation, and rapid repair, and TB500 has inherited these properties as well. Initially, in the research on thymosin β4, it was found to possess multiple biological activities, playing important roles in aspects such as cell migration, tissue repair, and inflammation regulation. TB500 is the active fragment of thymosin β4. Researchers hope that through the study of TB500, they can gain a deeper understanding of its mechanism of action and explore whether it can be developed into a drug with specific therapeutic purposes.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eIn the fields of wound repair and tissue damage caused by chronic diseases, traditional treatment methods have certain limitations. Due to its potential ability in promoting cell migration and tissue repair, TB500 has become a research hotspot, and people expect it to provide new ideas and methods for treating these diseases. For example, in the research of diseases such as myocardial infarction and nerve injury, studies are carried out to explore whether TB500 can promote the repair of damaged tissues and the restoration of their functions.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eAthletes are prone to various injuries during training and competitions, including muscle strains and ligament injuries. TB500 is believed to potentially help accelerate injury repair and improve the recovery speed of sports injuries, so it has attracted attention in the field of sports medicine. Some studies attempt to explore the application potential of TB500 in the rehabilitation of athletes' injuries. However, at the same time, it has also triggered a controversy about whether it may be abused as a doping. With the development of medicine, the demand for new drugs is constantly increasing. As a peptide substance with a unique mechanism of action, TB500 has the potential to be developed into a new type of drug, providing more options for clinical treatment.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003eWhat is the mechanism of action of TB500?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003ePromoting tissue regeneration:\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eTB500 is a small peptide processed from the active site of thymosin β4. Thymosin β4 has the ability to promote tissue regeneration, and TB500 has inherited this property. It may promote tissue regeneration in the following ways:\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003eActivating cell signaling pathways:\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eIt may activate certain specific cell signaling pathways to promote cell proliferation and differentiation. For example, it may activate signaling pathways related to cell growth and repair, such as the PI3K\/Akt signaling pathway, etc., thereby stimulating cell proliferation and differentiation and promoting tissue regeneration\u003csup\u003e[1]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003eRegulating the extracellular matrix:\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eThe extracellular matrix plays an important role in tissue regeneration. TB500 may regulate the synthesis and degradation of the extracellular matrix, promoting cell adhesion, migration, and tissue remodeling. For example, it may increase the synthesis of collagen and elastin, improving the structure and function of tissues\u003csup\u003e[1]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003eAnti-inflammatory effect:\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eInflammation is a defensive response of the body to injury and infection, but excessive inflammation can lead to tissue damage. TB500 has an anti-inflammatory effect and can inhibit the production of inflammatory mediators. Inflammatory mediators such as cytokines and chemokines play a key role in the inflammatory response. TB500 may inhibit the production of these inflammatory mediators, thereby reducing the inflammatory response. For example, it may inhibit the production of inflammatory factors such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β)\u003csup\u003e[1]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003eRegulating the function of immune cells:\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eImmune cells play an important role in the inflammatory response. TB500 may regulate the function of immune cells, such as regulating the activity of macrophages and lymphocytes, thereby reducing the inflammatory response. For example, it may promote the transformation of macrophages into an anti-inflammatory phenotype and inhibit the activation and proliferation of lymphocytes\u003csup\u003e[1]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003eAccelerating cell proliferation and differentiation:\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eBy activating cell signaling pathways and regulating the extracellular matrix, TB500 can accelerate cell proliferation and differentiation, promoting the repair of damaged tissues\u003csup\u003e[1]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003eReducing the inflammatory response: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eThe inflammatory response will delay tissue repair, and the anti-inflammatory effect of TB500 can reduce the inflammatory response, creating a favorable environment for tissue repair\u003csup\u003e[1]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003ePromoting angiogenesis: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eAngiogenesis is crucial for tissue repair. TB500 may promote angiogenesis, increasing the blood supply to damaged tissues, providing nutrients and oxygen for cells, and promoting tissue repair\u003csup\u003e[1]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-indent: 0em; text-align: left;\"\u003e\u003cem\u003e\u003cimg class=\"shrinkToFit\" height=\"951\" width=\"1647\" alt=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332223002603-gr1_lrg.jpg\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332223002603-gr1_lrg.jpg\"\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp style=\"text-indent: 0em; text-align: left;\"\u003e\u003cem\u003eRegulation of MMP\/TIMP on hepatic fibrosis.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eSource:PubMed\u003csup\u003e[3]\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003eHow does TB500 regulate the synthesis and degradation of the extracellular matrix?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eThe balance between the synthesis and degradation of the extracellular matrix (ECM) is essential for maintaining the normal structure and function of tissues. TB-500 may affect the synthesis of the extracellular matrix in the following ways:\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003ePromoting collagen deposition:\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eTB-500 is believed to be able to promote collagen deposition, and collagen is an important component of the extracellular matrix. The specific mechanism of action may involve the regulation of cell signaling pathways involved in collagen synthesis. For example, it may promote the expression of collagen genes by activating certain growth factors or transcription factors, thereby increasing the synthesis of collagen\u003csup\u003e[2]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003ePromoting endothelial cell differentiation and angiogenesis:\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eEndothelial cells secrete a variety of extracellular matrix components during the process of blood vessel formation. TB-500 promotes endothelial cell differentiation and angiogenesis in dermal tissues, which may indirectly promote the synthesis of the extracellular matrix. The newly formed blood vessels require the support of the extracellular matrix, which may stimulate cells to synthesize more extracellular matrix components\u003csup\u003e[2]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003eInfluence on the degradation of the extracellular matrix:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003eIt may regulate the activities of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs):\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eThe degradation of the extracellular matrix is mainly regulated by matrix metalloproteinases and their inhibitors. Although there is currently no direct evidence that TB-500 regulates the activities of MMPs and TIMPs, considering that TB-500 has the effects of promoting cell migration and wound healing, and the processes of cell migration and wound healing are usually accompanied by the remodeling of the extracellular matrix, this may involve the regulation of MMPs and TIMPs. For example, in the study of liver fibrosis, matrix metalloproteinases and their specific inhibitors (i.e., tissue inhibitors of metalloproteinases, TIMPs) play a key role in collagen synthesis and dissolution. By restoring the balance between MMPs and TIMPs, the accumulation of the extracellular matrix can be inhibited, thereby reducing liver fibrosis\u003csup\u003e[3]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003eIndirectly regulating the degradation of the extracellular matrix by affecting cell behavior:\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eTB-500 can promote keratinocyte migration. During the process of cell migration, cells need to regulate the degradation of the extracellular matrix to clear the way. This may involve the secretion of certain enzymes or factors by cells to regulate the degradation of the extracellular matrix. For example, in some physiological and pathological processes, cells secrete matrix metalloproteinases to degrade the extracellular matrix for migration\u003csup\u003e[2]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003eIn what ways does TB500 interact with biomaterials to promote muscle regeneration?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003eRelease of bioactive molecules:\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eBiomaterials can serve as carriers and act in concert with TB500 to release bioactive molecules, promoting muscle regeneration. For example, some biomaterials can release active substances such as growth factors. These substances work together with TB500 to stimulate the proliferation and differentiation of muscle cells. TB500 itself has the effects of promoting cell migration and angiogenesis. Combined with the active molecules released by biomaterials, it can more effectively promote muscle regeneration\u003csup\u003e[4, 5]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003eThe role of biomimetic materials:\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eBiomimetic materials mimic the natural structure and function of muscle tissues, providing a suitable microenvironment for TB500. Such biomimetic materials can be better compatible with muscle tissues, promoting the action of TB500 at the damaged site. For example, biomimetic materials with a specific pore structure can provide support for cell growth, and at the same time, allow TB500 to diffuse and function better\u003csup\u003e[4]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003eImmunomodulatory effect:\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eBiomaterials can promote muscle regeneration by regulating the immune system, in coordination with TB500. Studies have shown that biomaterials can regulate the polarization of macrophages, thereby controlling the immune response and creating a favorable environment for muscle regeneration. TB500 may further enhance this immunomodulatory effect by affecting the activity of immune cells. For example, through the immunomodulation mediated by biomaterials, the polarization of macrophages can be regulated to promote the soft tissue regeneration of the musculoskeletal system, and TB500 may play a synergistic role in this process\u003csup\u003e[5]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003eCombination of stem cells and biomaterials:\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eStem cells play an important role in muscle regeneration. Combining with biomaterials and TB500 can provide a more effective treatment strategy. Many stem cell populations, such as mesenchymal stem cells and adipose-derived stem cells, are involved in muscle regeneration. Biomaterials can provide support and guidance for stem cells, while TB500 can promote the migration, survival, and differentiation of stem cells. The combination of the three can overcome the limitations of using them alone and promote muscle regeneration.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003ePromotion of nerve regeneration: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003ePeripheral nerve regeneration also plays a key role in muscle regeneration. Biomaterials can provide structural bridging to promote nerve regeneration, and TB500 may further promote nerve regeneration and muscle function recovery by affecting the gene expression related to neurogenesis. For example, some studies have found that the gene arrays related to neurogenesis are upregulated, suggesting the role of peripheral nerve regeneration in mediating the recovery of muscle force, and biomaterials and TB500 may jointly promote this process\u003csup\u003e[6]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003e\u003cstrong\u003eApplication of magnetically responsive biomaterials:\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eNew magnetically responsive biomaterials can enhance muscle regeneration by triggering drug and cell delivery. TB500 can be used in combination with such biomaterials to improve the repair effect of damaged muscles. For example, a biphasic iron gel scaffold can be used to deliver cells and growth factors, precisely timing in vivo to enhance functional muscle regeneration during inflammation. TB500 may act synergistically with this biomaterial to further promote muscle regeneration\u003csup\u003e[7]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left; text-indent: 0em;\"\u003eOverall, as a small peptide processed from the active site of thymosin β4, TB500 has shown remarkable potential in tissue regeneration, anti-inflammation, and rapid repair. Research has found that it can promote endothelial cell differentiation, angiogenesis, and keratinocyte migration, and may also regulate the synthesis and degradation of the extracellular matrix. In the field of muscle repair, TB500 may bring new hope for the repair of sports injuries by promoting the proliferation and differentiation of muscle stem cells, regulating the inflammatory response, and interacting with biomaterials. TB500 has the potential to become an effective drug for the adjuvant treatment of tissue damage and related diseases.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"prod_describe_new_3\" class=\"prod_describe_new3\"\u003e\n\u003cdiv class=\"prod_describe_new_content\"\u003e\n\u003cdiv class=\"prodDetail-editor-container sliderTable\"\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong style=\"font-size: 24px;\"\u003eRelevant Citations\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[1] Rahaman K, Muresan A, Son J, et al. Development of analytical methods for TB-500 and its metabolites by LC-MS\/MS[M]. 2022.10.13140\/RG.2.2.32176.02564.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[2] Ho E N M, Kwok W H, Lau M Y, et al. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β4, in equine urine and plasma by liquid chromatography-mass spectrometry[J]. Journal of Chromatography A, 2012,1265:57-69.DOI:10.1016\/j.chroma.2012.09.043.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[3] Shan L, Wang F, Zhai D, et al. Matrix metalloproteinases induce extracellular matrix degradation through various pathways to alleviate hepatic fibrosis[J]. Biomedicine \u0026amp; Pharmacotherapy, 2023,161.DOI:10.1016\/j.biopha.2023.114472.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[4] Carleton M M, Sefton M V. Promoting endogenous repair of skeletal muscle using regenerative biomaterials[J]. Journal of Biomedical Materials Research Part A, 2021,109(12):2720-2739.DOI:10.1002\/jbm.a.37239.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[5] Ye J, Xie C, Wang C, et al. Promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarization[J]. Bioactive Materials, 2021,6(11):4096-4109.DOI:10.1016\/j.bioactmat.2021.04.017.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[6] Roberts K, Kim J T, Huynh T, et al. Transcriptome profiling of a synergistic volumetric muscle loss repair strategy[J]. Bmc Musculoskeletal Disorders, 2023,24(1).DOI:10.1186\/s12891-023-06401-1.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[7] Cezar C A. Magnetically Responsive Biomaterials for Enhanced Skeletal Muscle Regeneration[M]. 2015.https:\/\/www.proquest.com\/dissertations-theses\/magnetically-responsive-biomaterials-enhanced\/docview\/1761573755\/se-2.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"prod_describe_new3\" id=\"prod_describe_new_2\"\u003e\n\u003cdiv class=\"prod_describe_new_content\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"prod_describe_new3\" id=\"prod_describe_new_3\"\u003e\n\u003cdiv class=\"prod_describe_new_content\"\u003e\n\u003cdiv class=\"prodDetail-editor-container sliderTable\"\u003e\n\u003cdiv class=\"prod_describe_new3\" id=\"prod_describe_new_2\"\u003e\n\u003cdiv class=\"prod_describe_new_content\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"prod_describe_new3\" id=\"prod_describe_new_3\"\u003e\n\u003cdiv class=\"prod_describe_new_content\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp data-start=\"293\" data-end=\"654\"\u003e\u003cstrong\u003eFor Research Use Only\u003c\/strong\u003e\u003cbr data-start=\"321\" data-end=\"324\"\u003eThis compound is provided exclusively for in vitro laboratory research. It is not intended for human or animal consumption, diagnosis, treatment, or medical use. Not for dietary, cosmetic, or veterinary purposes. This product has not been evaluated by the U.S. Food and Drug Administration or any other regulatory authority.\u003c\/p\u003e\n\u003chr data-start=\"656\" data-end=\"659\"\u003e\n\u003cp data-start=\"661\" data-end=\"910\"\u003e\u003cstrong\u003eDisclaimer\u003c\/strong\u003e\u003cbr data-start=\"675\" data-end=\"678\"\u003eAll information is for educational purposes only. Humatide makes no claims regarding efficacy or safety. Purchasers are responsible for ensuring proper handling and use in compliance with all applicable laws and regulations.\u003c\/p\u003e\n\u003chr data-start=\"912\" data-end=\"915\"\u003e\n\u003cp data-start=\"917\" data-end=\"1259\"\u003e\u003cstrong\u003eTerms of Sale\u003c\/strong\u003e\u003cbr data-start=\"934\" data-end=\"937\"\u003eBy purchasing from Humatide, you confirm that you are a qualified researcher with the knowledge and facilities to safely handle and store research chemicals. All sales are final. Humatide assumes no liability for misuse, misrepresentation, or unintended consequences arising from the use of this product.\u003c\/p\u003e","brand":"Humatide","offers":[{"title":"500mcg","offer_id":46452583694526,"sku":null,"price":250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0748\/8667\/6670\/files\/TB-500Caps_b95ed3bb-8c2d-45b6-b711-be58da6c9915.jpg?v=1781296303","url":"https:\/\/shop.humatide.com\/products\/tb-500-500mcg-120-capsules","provider":"Humatide","version":"1.0","type":"link"}