{"product_id":"selank","title":"Selank","description":"\u003ch2\u003e\u003cstrong\u003eSelank Description\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003eSelank, a synthetic peptide drug, is primarily used to improve anxiety, depression, and cognitive dysfunction. It exhibits anxiolytic and antidepressant effects, effectively alleviating anxiety and reducing depressive symptoms while significantly enhancing cognitive functions, including memory, attention, and learning abilities. Additionally, Selank has immunomodulatory effects, capable of enhancing the body's immune function. It is safe, well-tolerated, easy to use, and fast-acting. Selank is not only significant in the treatment of mental disorders, providing new options for conditions such as anxiety and depression, but also demonstrates potential value in neuroprotection and cognitive improvement, especially suitable for cases where conventional medications are ineffective or have side effects, helping to improve mental state and quality of life.\u003c\/p\u003e\n\u003ch3 class=\"text-lg font-bold text-text-100 mt-1 -mb-1.5\"\u003ePeptide Information\u003c\/h3\u003e\n\u003ctable class=\"bg-bg-100 min-w-full border-separate border-spacing-0 text-sm leading-[1.88888] whitespace-normal\" style=\"width: 100%; height: 138.867px;\"\u003e\n\u003cthead class=\"border-b-border-100\/50 border-b-[0.5px] text-left\"\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003cth class=\"text-text-000 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003eProperty\u003c\/th\u003e\n\u003cth class=\"text-text-000 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003eValue\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003ePeptide Sequence\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003eThr-Lys-Pro-Arg-Pro-Gly-Pro\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 21.2667px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 21.2667px;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 21.2667px;\"\u003eC\u003csub\u003e33\u003c\/sub\u003eH\u003csub\u003e57\u003c\/sub\u003eN\u003csub\u003e11\u003c\/sub\u003eO\u003csub\u003e9\u003c\/sub\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003e751.87 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003e129954-34-3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003e11765600\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSelanc\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong style=\"font-size: 24px;\"\u003eSelank Research\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eNeuroadaptation and the Endogenous Opioid System: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eThe endogenous opioid system is involved in the neuroadaptation process caused by exogenous opioids. Selank, an anxiolytic synthesized based on the regulatory peptide tuftsin, can inhibit the activity of enkephalin-degrading enzymes, thus increasing the level of leucine enkephalin in the plasma (Nadorova A V, 2022). This indicates that Selank may exert its effects by regulating the endogenous opioid system.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eAnxiety and mood disorders are among the most common mental health problems globally. Commonly used clinical anxiolytic drugs mainly focus on the pharmacological regulation of the activity of the brain's GABA receptor system. However, such drugs usually have a series of clinical problems such as dependence and memory impairment (Vyunova T V, 2018). There is an increasing recognition of the role of neuropeptides and bioactive lipids in the pathophysiology of mood and anxiety disorders. The heptapeptide Selank exhibits long-term anxiolytic and nootropic effects (Vyunova T V, 2018).\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eWhat is the mechanism of action of Selank?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eWhat is the mechanism of action of Selank on anxiety and mood disorders?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eRegulating the GABA Receptor System: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eAnxiety and mood disorders are the most common mental health problems globally. Commonly used clinical anxiolytic drugs mainly exert their effects by regulating the activity of the GABA receptor system in the brain, but they often have problems such as dependence and memory impairment. Studies have found that the heptapeptide Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) has a therapeutic effect on anxiety and mood disorders. Radioligand-receptor analysis methods have shown that Selank affects [3H] GABA binding as a positive allosteric modulator. The combined action of Selank with certain benzodiazepines also regulates the [3H] GABA binding activity in a specific way. This effect is not additive and is different from using either substance alone. Selank can block the regulatory activities of diazepam and olanzapine. Its binding site is apparently different from those of these drugs, but may partially overlap\u003csup\u003e[1]\u003c\/sup\u003e. It is thus speculated that one of the molecular mechanisms of Selank's anxiolytic effect may be related to the subtype-selective concentration-dependent allosteric regulation of GABA receptors.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eWhat is the mechanism of Selank in relieving the analgesia induced by morphine?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eInhibiting Morphine Withdrawal Reaction: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eSome studies have shown that the peptide substance Selank can weaken the withdrawal reaction of rats to morphine at a certain dose. For example, in the morphine withdrawal model induced by naloxone, a single intraperitoneal injection of Selank (0.3mg\/kg) can reduce the total index of the morphine withdrawal syndrome by 39.6%, significantly alleviate symptoms such as convulsive reactions, ptosis, and postural disorders, and increase the tactile sensitivity threshold of morphine-dependent rats by 9 times \u003csup\u003e[2]\u003c\/sup\u003e. This indicates that Selank may indirectly affect the analgesic mechanism of morphine by regulating the nervous system's dependence on morphine.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eSynergistic Analgesic Effect with Morphine: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eIn animal experiments, researchers found that Selank shows a synergistic analgesic effect when used in combination with morphine. Morphine can cause a certain degree of analgesia at a certain dose, and although Selank itself has no obvious analgesic effect, when used in combination with morphine at a specific dose (0.9mg\/kg), it can increase the latency of mice's response to thermal stimuli, enhancing the analgesic effect to 29.9% of the maximum possible effect (MBE)\u003csup\u003e[3]\u003c\/sup\u003e. This indicates that Selank may enhance the analgesic effect of morphine through a certain pathway.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eActing on the Enkephalin System: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eBased on the study of the physiological effects of Selank and its fragments, it is speculated that Selank acts on the network of the cascade process of peptides and mediators through enkephalin. Enkephalin is a type of endogenous opioid peptide and plays an important role in pain regulation. Selank may affect the analgesic effect of morphine by regulating the activity of enkephalin-degrading enzymes and increasing the level of leucine enkephalin in the plasma \u003csup\u003e[4]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cimg data-original=\"https:\/\/website.leadong.com\/ueditor\/themes\/default\/images\/spacer.gif\" data-src=\"https:\/\/website.leadong.com\/ueditor\/themes\/default\/images\/spacer.gif\" class=\"lazyimg\" src=\"https:\/\/website.leadong.com\/ueditor\/themes\/default\/images\/spacer.gif\"\u003e\u003cimg\u003e\u003cimg\u003e\u003cimg alt=\"\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0748\/8667\/6670\/files\/selankstudy_3c3832eb-3465-484a-81a8-7bb23a865cb8.png?v=1769915756\"\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cem\u003eEffects of Selank (0.3 mg\/kg) on the recognition of the novel object in rats subjected to forced alcoholization.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eSource:PubMed\u003csup\u003e[7]\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eWhat is the potential principle of Selank in treating the weakness disorder in post-COVID syndrome?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eBased on Immunomodulatory Effects: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eConsidering the dominant role of immune disorders in the pathogenesis of COVID-19, drugs with immunomodulatory effects seem promising in the treatment of post-COVID syndrome. Selank is a peptide drug created based on the immunomodulator tafcin. In the treatment of post-COVID syndrome, Selank may relieve weakness symptoms by regulating the immune system and correcting immune dysfunction. For example, Selank may have a direct activity on immune interactions or act indirectly by reducing the post-stress response, thereby maintaining the normal state of immune function\u003csup\u003e[5]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eAnxiolytic and Improving Mood Disorders: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eIn post-COVID syndrome, patients often experience mood disorders such as anxiety and depression, accompanied by weakness and decreased performance. Studies have shown that Selank can relieve symptoms of anxiety and depression during the treatment process. Its mechanism of action may be related to Selank's regulation of the neurotransmitter system in the brain. For example, Selank may act as a positive allosteric modulator to affect [3H] GABA binding, thereby regulating the activity of the GABA receptor system and exerting an anxiolytic effect \u003csup\u003e[1]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eNeuroprotective Effect: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eIn the study, patients were divided into two groups. One group used a neuroprotective complex (cholitilin, mexidol, milgamma) and Selank, and the other group used only the neuroprotective complex. The results showed that patients using Selank had better effects in terms of weakness and decreased mental performance. This indicates that Selank may act synergistically with the neuroprotective complex to exert a neuroprotective effect, thus improving the weakness symptoms of patients \u003csup\u003e[5]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eAntiviral Effect: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eStudies have found that Selank has antiviral properties in experimental influenza infections. Although there is currently no direct evidence that Selank has an antiviral effect against the COVID-19 virus, given its performance in influenza virus infections, Selank may have a certain impact on the COVID-19 virus through a certain mechanism, thus helping to treat the weakness disorder in post-COVID syndrome. For example, in in vivo studies, Selank induced the gene expression of interferon-α (IFN-α), which may help enhance the body's antiviral ability\u003csup\u003e[6]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eWhat are the effects of Selank?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eAnxiolytic and Improving Mood Disorders: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eIn post-COVID syndrome, patients often experience mood disorders such as anxiety and depression, accompanied by weakness and decreased performance. Studies have shown that Selank can relieve symptoms of anxiety and depression during the treatment process. Its mechanism of action may be related to Selank's regulation of the neurotransmitter system in the brain. For example, Selank may act as a positive allosteric modulator to affect [3H] GABA binding, thereby regulating the activity of the GABA receptor system and exerting an anxiolytic effect \u003csup\u003e[1]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eNeuroprotective Effect:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eIn the study, patients were divided into two groups. One group used a neuroprotective complex (cholitilin, mexidol, milgamma) and Selank, and the other group used only the neuroprotective complex. The results showed that patients using Selank had better effects in terms of weakness and decreased mental performance. This indicates that Selank may act synergistically with the neuroprotective complex to exert a neuroprotective effect, thus improving the weakness symptoms of patients \u003csup\u003e[5]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eRelieving Analgesia Induced by Morphine: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eSome studies have shown that Selank, an anxiolytic synthesized based on the regulatory peptide tuftsin, has an impact on morphine-induced analgesia in animal models. For example, when the morphine dose is 3.0mg\/kg (intraperitoneal injection), it can cause antinociception, with a maximum possible effect (MBE) of 9%. While the Selank dose of 0.9mg\/kg has no antinociceptive effect by itself, when pre-treated with morphine, it can increase the latent reaction time and cause an antinociceptive effect of 29.9% MBE\u003csup\u003e[3]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eAlleviating the Aversive Symptoms of Morphine Withdrawal: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eThe activity of the peptide tuftsin analog Selank was studied in a morphine withdrawal model induced by naloxone. A single intraperitoneal injection of Selank at an anxiolytic dose of 0.3mg\/kg can reduce the total index of the morphine withdrawal syndrome by 39.6%, significantly (p＜0.0001) alleviate convulsive reactions, ptosis, and postural disorders, and increase the tactile sensitivity threshold of morphine-dependent rats by 9 times compared with the positive control group. At the same time, Selank is slightly inferior to diazepam at a dose of 2mg\/kg in terms of pharmacological activity (reducing the total index of the morphine withdrawal syndrome by 49.3% and increasing the sensitivity threshold by 13 times). Therefore, like diazepam, Selank can alleviate the aversive symptoms of morphine withdrawal in opioid dependence in rats \u003csup\u003e[2]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003ePreventing ethanol-induced memory impairment: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eIn rats that received 10% ethanol as their sole liquid source for up to 30 weeks, the effects of Selank, a peptide-based anxiolytic drug synthesized from the endogenous peptide tuftsin, on memory impairment and brain-derived neurotrophic factor (BDNF) levels were investigated. In object recognition tests, Selank exhibited cognitive-enhancing effects in 9-month-old rats not exposed to ethanol and prevented the development of ethanol-induced memory and attention impairments during alcohol withdrawal. In vitro experiments showed that Selank could inhibit ethanol-induced increases in BDNF levels in the hippocampus and prefrontal cortex. From the above, it can be concluded that this synaptogenic agent has a positive effect on age-related memory impairments associated with chronic alcohol dependence, and confirms that BDNF-related neurotrophic mechanisms are involved in the mechanism of action of Selank\u003csup\u003e[7]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eTreatment of Post-COVID-19 Syndrome: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003ePost-COVID-19 syndrome occurs following COVID-19 infection and may also be observed in cases of mild or asymptomatic disease. The most common symptoms of the bridge syndrome are fatigue and functional decline, followed by cognitive impairments. Given the central role of immune dysregulation in the pathogenesis of COVID-19, immunomodulatory drugs with direct immune-modulating effects or those that indirectly maintain immune function by reducing post-stress responses hold potential therapeutic promise.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eSelank is a peptide drug developed based on the immunomodulator tafcin, which is effective in treating various neuroses and neurosis-like disorders. When used at a dosage of 2-3 drops four times a day for 30 consecutive days, Selank has a good therapeutic effect on patients with fatigue and cognitive impairment. Relief of anxiety and depression symptoms can also be observed\u003csup\u003e[5]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eCorrecting cognitive and emotional disorders in patients with atopic dermatitis: A study analyzed cognitive and emotional disorders in 65 patients with atopic dermatitis (AD) and randomly divided the patients into two statistically comparable groups.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eThe first group of patients received standard drug therapy for atopic dermatitis (BT), while the second group received a combination of serank and BT via intranasal administration (S + BT), administered three times daily, with two drops instilled into each nostril per dose, for a total of 14 days. The control group consisted of 30 healthy individuals. Personal anxiety (LT), reactive anxiety (RT), yohimbine levels, blood β-endorphin levels, and quality of life (QOL) were assessed before treatment and 30 days after treatment initiation.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eThe study results showed that RT levels in AD patients were 4.2 times higher than those in the control group, LT levels were 3.2 times higher, and yekhtumia levels were 18 times higher. In the BT group, RT decreased by 1.4 times and LT decreased by 1.3 times 30 days after treatment initiation. In the C+BT group, the decreases in LT and RT were similarly significant, both by 2.4 times.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eThere were no significant changes in yekutumia symptoms or β-endorphin levels in the blood of patients in the BT group. In the S+BT group, Alexis emotional disorders decreased by 1.2 times, and β-endorphin levels in the blood increased by 1.9 times. The quality of life index of patients in the BT group decreased by 1.2 times 30 days after treatment initiation, while that of patients in the S+BT group decreased by 1.7 times. The conclusion is that elevated levels of personal anxiety, reactive anxiety, and yekhtumia in AD patients reduce their quality of life. The use of the regulatory peptide Selank in the comprehensive treatment of AD patients has a corrective effect on emotional and cognitive disorders, reducing levels of personal anxiety, reactive anxiety, and yekhtumia, increasing levels of β-endorphin in the blood, and improving patients' quality of life\u003csup\u003e[8]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eIn conclusion, as a synthetic peptide drug developed based on the natural peptide clusterin, Selank has shown multi-dimensional application potential in clinical practice and research. Its core value lies in providing new solutions for diseases such as anxiety disorders, stress-related disorders, memory impairment, and immune disorders by regulating the neurotransmitter system, enhancing immune function, and improving cognitive function. Clinical studies have confirmed that Selank can effectively relieve symptoms of anxiety and depression, improve the weakness and cognitive disorders in post-COVID syndrome, and synergistically enhance the anti-inflammatory effect in the treatment of atopic dermatitis. Compared with traditional drugs, it has fewer side effects, a longer duration of action, and shows unique advantages in the fields of analgesia, anti-addiction, and neuroprotection.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong style=\"font-size: 24px;\"\u003eRelevant Citations\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[1] Vyunova TV, Andreeva L, Shevchenko K, Myasoedov N. Peptide-Based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity. \u003cem\u003ePROTEIN PEPTIDE LETT\u003c\/em\u003e 2018; \u003cstrong\u003e25\u003c\/strong\u003e(10): 914-23.DOI:10.2174\/0929866525666180925144642.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[2] Konstantinopolsky MA, Chernyakova IV, Kolik LG. Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats. \u003cem\u003eB EXP BIOL MED+\u003c\/em\u003e 2022; \u003cstrong\u003e173\u003c\/strong\u003e(6): 730-3.DOI:10.1007\/s10517-022-05624-x.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[3] Nadorova AV, Chernyakova IV, Kolik LG. Selank effects on morphine-induced analgesia in vivo experiments. \u003cem\u003ePharmacokinetics and Pharmacodynamics\u003c\/em\u003e 2022.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eDOI:https:\/\/api.semanticscholar.org\/CorpusID:248608989.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[4] Koroleva SV, Mjasoedov NF. Physiological Effects of Selank and Its Fragments. BIOL BULL+ 2019; 46(4): 407-14.DOI:10.1134\/S1062359019040071.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[5] Pogodina M, Nikiforova E. Post-COVID Syndrome: Possibilities for Therapy of Asthenic Disorders with Selank. \u003cem\u003eVrach\u003c\/em\u003e 2024.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eDOI:https:\/\/api.semanticscholar.org\/CorpusID:270168582.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[6] Ershov FI, Uchakin PN, Uchakina ON, Mezentseva MV, Alekseyeva LA, Myasoyedov NF. Antiviral activity of immunomodulator Selank in experimental influenza infection. \u003cem\u003eVoprosy Virusologii\u003c\/em\u003e 2009; \u003cstrong\u003e54\u003c\/strong\u003e(5): 19-24.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[7] Kolik LG, Nadorova AV, Antipova TA, Kruglov SV, Kudrin VS, Durnev AD. Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats. \u003cem\u003eB EXP BIOL MED+\u003c\/em\u003e 2019; \u003cstrong\u003e167\u003c\/strong\u003e(5): 641-4.DOI:10.1007\/s10517-019-04588-9.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[8] Kruglova LS, Novikova LA, Dontsova EV, Borzunova LN, Kova NAV. Possibilities of cognitive-affective disorders correction in patients with atopic dermatitis using selanc regulatory peptide. \u003cem\u003eКурский\u003c\/em\u003e\u003cem\u003e \u003c\/em\u003e\u003cem\u003eнаучно\u003c\/em\u003e\u003cem\u003e-\u003c\/em\u003e\u003cem\u003eпрактический\u003c\/em\u003e\u003cem\u003e \u003c\/em\u003e\u003cem\u003eвестник\u003c\/em\u003e\u003cem\u003e «\u003c\/em\u003e\u003cem\u003eЧеловек\u003c\/em\u003e\u003cem\u003e \u003c\/em\u003e\u003cem\u003eи\u003c\/em\u003e\u003cem\u003e \u003c\/em\u003e\u003cem\u003eего\u003c\/em\u003e\u003cem\u003e \u003c\/em\u003e\u003cem\u003eздоровье\u003c\/em\u003e\u003cem\u003e»\u003c\/em\u003e 2020.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003ehttps:\/\/api.semanticscholar.org\/CorpusID:234612442.https:\/\/pubmed.ncbi.nlm.nih.gov\/19882898\/\u003c\/p\u003e\n\u003cp data-start=\"293\" data-end=\"654\"\u003e\u003cstrong\u003eFor Research Use Only\u003c\/strong\u003e\u003cbr data-start=\"321\" data-end=\"324\"\u003eThis compound is provided exclusively for in vitro laboratory research. It is not intended for human or animal consumption, diagnosis, treatment, or medical use. Not for dietary, cosmetic, or veterinary purposes. This product has not been evaluated by the U.S. Food and Drug Administration or any other regulatory authority.\u003c\/p\u003e\n\u003chr data-start=\"656\" data-end=\"659\"\u003e\n\u003cp data-start=\"661\" data-end=\"910\"\u003e\u003cstrong\u003eDisclaimer\u003c\/strong\u003e\u003cbr data-start=\"675\" data-end=\"678\"\u003eAll information is for educational purposes only. Humatide makes no claims regarding efficacy or safety. Purchasers are responsible for ensuring proper handling and use in compliance with all applicable laws and regulations.\u003c\/p\u003e\n\u003chr data-start=\"912\" data-end=\"915\"\u003e\n\u003cp data-start=\"917\" data-end=\"1259\"\u003e\u003cstrong\u003eTerms of Sale\u003c\/strong\u003e\u003cbr data-start=\"934\" data-end=\"937\"\u003eBy purchasing from Humatide, you confirm that you are a qualified researcher with the knowledge and facilities to safely handle and store research chemicals. All sales are final. Humatide assumes no liability for misuse, misrepresentation, or unintended consequences arising from the use of this product.\u003c\/p\u003e","brand":"Humatide","offers":[{"title":"10MG","offer_id":46015454412990,"sku":null,"price":30.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0748\/8667\/6670\/files\/Selank.jpg?v=1781294009","url":"https:\/\/shop.humatide.com\/products\/selank","provider":"Humatide","version":"1.0","type":"link"}