{"product_id":"melanotan-2","title":"Melanotan 2","description":"\u003ch2\u003e\u003cstrong\u003eMelanotan 2 Description\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003eMelanotan is a synthetic metabolic peptide. It stimulates melanocytes to accelerate melanin production, thus speeding up tanning. Even with low UV exposure, it can quickly darken the skin and achieve the desired tanning effect. Additionally, it helps reduce UV-induced skin damage and lowers the risks of skin cancer and sunburn. Melanotan also interacts with appetite-regulating receptors to assist in weight control. Clinical trials have demonstrated its ability to enhance male erections and libido, as well as increase female libido, making it a potential treatment for sexual dysfunction. For fair-skinned individuals, it provides a safer and more effective tanning method. Moreover, it strengthens the skin's natural defense, reduces UV-caused damage, and thus offers partial protection for skin health. \u003cbr\u003e  \u003c\/p\u003e\n\u003ch3 class=\"text-lg font-bold text-text-100 mt-1 -mb-1.5\"\u003ePeptide Information\u003c\/h3\u003e\n\u003ctable class=\"bg-bg-100 min-w-full border-separate border-spacing-0 text-sm leading-[1.88888] whitespace-normal\" style=\"width: 100%; height: 138.867px;\"\u003e\n\u003cthead class=\"border-b-border-100\/50 border-b-[0.5px] text-left\"\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003cth class=\"text-text-000 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003eProperty\u003c\/th\u003e\n\u003cth class=\"text-text-000 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003eValue\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003ePeptide Sequence\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003e\n\u003cdiv class=\"text-left sm:table-cell sm:p-2 sm:border-t sm:border-gray-300 dark:sm:border-gray-300\/20 pb-1 pl-2 sm:align-middle\"\u003e\n\u003cdiv class=\"break-words space-y-1\"\u003e\n\u003cdiv class=\"text-left sm:table-cell sm:p-2 sm:border-t sm:border-gray-300 dark:sm:border-gray-300\/20 pb-1 pl-2 sm:align-middle\"\u003e\n\u003cdiv class=\"break-words space-y-1\"\u003eAc-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-NH₂\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 21.2667px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 21.2667px;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 21.2667px;\"\u003eC\u003csub\u003e50\u003c\/sub\u003eH\u003csub\u003e69\u003c\/sub\u003eN\u003csub\u003e15\u003c\/sub\u003eO\u003csub\u003e9\u003c\/sub\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003e1024.2 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003e121062-08-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003e92432\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eMT-II\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"tab-content active\" id=\"tab-description\"\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cdiv id=\"prod_describe_new_2\" class=\"prod_describe_new3\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"prod_describe_new3\" id=\"prod_describe_new_3\"\u003e\n\u003cdiv class=\"prod_describe_new_content\"\u003e\n\u003cdiv class=\"prodDetail-editor-container sliderTable\"\u003e\n\u003cdiv class=\"prod_describe_new3\" id=\"prod_describe_new_2\"\u003e\n\u003cdiv class=\"prod_describe_new_content\"\u003e\n\u003cdiv id=\"prod_describe_new_2\" class=\"prod_describe_new3\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"prod_describe_new3\" id=\"prod_describe_new_3\"\u003e\n\u003cdiv class=\"prod_describe_new_content\"\u003e\n\u003cdiv id=\"prod_describe_new_3\" class=\"prod_describe_new3\"\u003e\n\u003cdiv class=\"prod_describe_new_content\"\u003e\n\u003cdiv class=\"prodDetail-editor-container sliderTable\"\u003e\n\u003cdiv class=\"prod_describe_new3\" id=\"prod_describe_new_2\"\u003e\n\u003cdiv class=\"prod_describe_new_content\"\u003e\n\u003cdiv class=\"prodDetail-editor-container sliderTable\"\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong style=\"font-size: 24px;\"\u003eMelanotan-2 Research\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eWhat is the research background of Melanotan ?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eMelanotan is a synthetic analogue. It is a synthetic analogue of α-melanocyte-stimulating hormone (α-MSH), which is prepared by chemical synthesis methods\u003csup\u003e[1]\u003c\/sup\u003e . α-MSH is a naturally occurring hormone that has various physiological functions in the human body, including regulating skin pigmentation. Melanotan was designed to mimic some of the effects of α-MSH but has stronger activity and specific application purposes. Melanota was initially developed as a substance to promote skin pigmentation, that is, a so-called tanning agent. With the increase in people's demand for tanning, some people began to seek to obtain a rapid skin darkening effect by injecting Melanotan. The research in this regard mainly focuses on its mechanism and effect on skin pigmentation. For example, studies have found that Melanotan can bind to specific receptors on melanocytes to stimulate the production of melanin, thereby darkening the skin \u003csup\u003e[2, 3]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eWhat is Melanotan ?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eMelanotan is a synthetic analogue that is related to α-melanocyte-stimulating hormone (α-MSH). Its main function is to increase skin pigmentation and darken human skin. Melanotan mainly exerts its effect by interacting with melanocortin receptors. Specifically, as a non-selective melanocortin receptor agonist, it can stimulate the production of melanin in the skin, thus achieving skin pigmentation, that is, the tanning effect. In addition, it can also produce spontaneous penile erection and sexual stimulation effects.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eWhat is the specific mechanism of Melanota in tanning?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eMelanotan induces skin tanning by interacting with the melanocortin 1 receptor on melanocytes. It is believed that Melanotan mimics the effect of the melanocortin α-melanocyte-stimulating hormone (α-MSH) on the MC1 receptor of melanocytes, resulting in an increase in the expression of agouti signaling protein. Melanotan stimulates melanocytes to produce and secrete melanin, thereby increasing skin pigmentation\u003csup\u003e[4]\u003c\/sup\u003e. It can promote the production of eumelanin in the skin to achieve skin pigmentation. Studies have shown that the α-melanocyte-stimulating hormone (α-MSH) analogue cyclic -[Ac-Nle(4), Asp(5), D-Phe(7), Lys(10)] alpha-MSH-(4 - 10) amide (Melanota ), a potent melanocortin receptor agonist, can stimulate the production of eumelanin to achieve skin pigmentation\u003csup\u003e[5]\u003c\/sup\u003e .\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eWhat is the specific mechanism of Melanotan in inducing penile erection and enhancing sexual stimulation?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eInduction of erection: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eIn anesthetized rats, Melanotan —a non-specific melanocortin receptor agonist—exhibited dose-dependent erectile induction when administered via intravenous injection (0.1–1 mg\/kg) or hypothalamic paraventricular nucleus infusion (0.1–1 μg). This effect triggered penile erections and reduced the latency of first erectile events \u003csup\u003e[6]\u003c\/sup\u003e.Its effect may involve activating melanocortin receptors in the central nervous system, thereby regulating the neural pathways related to erection. When Melanotan is intrathecally injected (0.2 μg) at the L6 - S1 level, the amplitude of erection events is higher. This indicates that the neural pathways at the spinal cord level may also be involved in the induction of erection by Melanotan \u003csup\u003e[6]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003ePromotion of erection: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eAfter intravenous injection of Melanotan (1 mg\/kg), the erectile response induced by cavernous nerve stimulation is increased, thus playing a promoting role in erection\u003csup\u003e[6]\u003c\/sup\u003e . After acute removal of the lumbar paravertebral sympathetic chain, the promoting effect of Melanotan is abolished. This indicates that the promoting effect of Melanotan on erection depends on the integrity of the lumbar paravertebral sympathetic chain. In contrast, Melanota injected into the corpus cavernosum (1 μg) did not show any promoter activity. Spinal cord transection or bilateral transection of the pelvic nerve or the dorsal nerve of the penis did not impair the promoting activity of intravenous Melanotan (1 mg\/kg), further indicating that the promoting effect of Melanotan on erection is mainly through the sympathetic nerve pathway rather than the pelvic nerve or the dorsal nerve of the penis \u003csup\u003e[6]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eEnhancement of female sexual arousal behavior: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eStudies have found that Melanotan also has an impact on female sexual behavior. In female rats, ovariectomized rats pretreated with estradiol benzoate (EB) and progesterone (P), intravenous injection of Melanotan (1 and 3 mg\/kg) increased the number of jumps, rushes, and ear wiggles, indicating that progesterone can interact with Melanotan to increase female sexual arousal behavior \u003csup\u003e[7]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cimg data-v-f1e6d48c=\"\" alt=\"\" data-nuxt-img=\"\" srcset=\"https:\/\/mdpi-res.com\/ijms\/ijms-21-00681\/article_deploy\/html\/images\/ijms-21-00681-g001.png 1x, https:\/\/mdpi-res.com\/ijms\/ijms-21-00681\/article_deploy\/html\/images\/ijms-21-00681-g001.png 2x\" class=\"aspect-auto object-contain\" role=\"presentation\" src=\"https:\/\/mdpi-res.com\/ijms\/ijms-21-00681\/article_deploy\/html\/images\/ijms-21-00681-g001.png\"\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cem\u003eEffect of MTII on tumorigenicity of melanoma cells.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eSource:PubMed\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eMelanota is a substance with multiple functions and research directions. The following will introduce other related research on Melanota .\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eInduction of erection:\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eIn some studies, it was found that Melanotan also has an impact on the reproductive system. For example, Melanotan can cause abnormal penile erection. Some patients experienced painful erections after subcutaneous injection of Melanotan , and also showed symptoms of sympathetic nerve excitation, such as increased heart rate, elevated blood pressure, restlessness, and excessive sweating\u003csup\u003e[8]\u003c\/sup\u003e .This indicates that Melanotan may affect the blood supply and neural regulation of the reproductive organs by acting on specific neurotransmitters and receptor systems, thus leading to changes in erectile function. In addition, in studies on rodents, melanocortin substances can cause a lordosis posture, which is interpreted as evidence of increased sexual arousal\u003csup\u003e[8]\u003c\/sup\u003e, further suggesting that the impact of Melanotan on the reproductive system may be related to sexual arousal and the regulation of sexual behavior.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003ePromotion of melanin production: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eAs a synthetic melanocortin analogue, Melanotan can bind to the melanocortin I receptor (MC1R) to promote melanin production \u003csup\u003e[9]\u003c\/sup\u003e.It mainly achieves this by promoting the proliferation of melanocytes and regulating the activity of tyrosinase. This effect of promoting melanin production gives Melanotan potential application value in the field of skin, for example, it may play a role in the treatment and prevention of some skin diseases.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eResearch in anti-tumor aspects: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eIn the research on anti-tumor, studies using the B16-F10 melanoma model found that although Melanotan has no effect on the proliferation of melanoma cells, it can effectively inhibit the migration, invasion, and colony formation ability of melanoma cells. Local application of Melanotan can also significantly attenuate the tumor progression in mice with established melanoma. Its mechanism of action is to cause an upregulation of phosphatase and tensin homolog (PTEN) through the melanocortin 1 receptor (MC1R), thereby inhibiting the progression of melanoma by downregulating the cyclooxygenase II (COX-2)\/prostaglandin E2 (PGE2) signaling pathway \u003csup\u003e[1]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eTherapeutic effect on autism: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eSome studies used a maternal immune activation (MIA) mouse model of autism to evaluate the therapeutic potential of the melanocortin receptor 4 agonist M Melanotan for autism-like characteristics in adult male mice\u003csup\u003e[10]\u003c\/sup\u003e.Male MIA mice showed autism-like characteristics, including impaired social behavior indicators, reduced vocal communication, and increased repetitive behaviors. Administration of Melanotan to male MIA mice for seven consecutive days led to an improvement in social behavior indicators. There was no significant change in social behavior indicators in male C57 mice with a normal background after treatment with Melanotan. In addition, in normal C57 mice, there were no changes in anxiety-like or repetitive behaviors after treatment with Melanotan, but there was a significant decrease in body weight after subacute treatment. These data indicate that Melanotan is an effective drug that can improve the autism-like behavioral deficits in the autism model of adult male MIA mice.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eReversal of memory impairment:\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eStudies have shown that a high-fat (HF) diet has been proven to increase the risk of nerve damage and neurodegenerative diseases. This study investigated the possible relationship between diet, Melanotan targeting melanocortin receptors, and the behavior of zebrafish\u003csup\u003e[11]\u003c\/sup\u003e . Surprisingly, even a short-term HF diet that lasted for about 1% of the zebrafish's life had a strong developmental impact. Compared with zebrafish fed a control diet, zebrafish fed an HF diet showed impaired recognition memory, increased anxiety levels, and reduced exploration tendency after only three weeks. And these abnormalities caused by the HF diet were reversed by Melanotan. Animals fed an HF diet and treated with Melanota showed recognition memory, anxiety, and exploration behaviors similar to those of the control group. This study provides evidence that even a short-term HF diet can have an impact on memory and mood, and it is the first study to show that Melanotan can reverse these changes.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eRegulation of social behavior: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eIn the field of neuroscience research, it was found that Melanotan-II can regulate social behavior by stimulating melanocortin receptors and then activating the central oxytocin system \u003csup\u003e[12]\u003c\/sup\u003e. Specifically, after systemic administration of Melanotan , intravenous injection rather than intranasal administration of Melanotan can significantly induce Fos expression in the magnocellular neurons of the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the hypothalamus, and this response can be attenuated by pretreatment with the melanocortin antagonist SHU-9119. Electrophysiological recordings showed that intravenous injection of Melanotan can increase the firing rate of oxytocin neurons in the SON. This indicates that Melanotan has a regulatory effect on the oxytocin system related to social behavior in the nervous system, and its mechanism of action may be to regulate the activity and secretion of oxytocin neurons by activating specific receptors and signaling pathways.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eResearch on obesity and metabolic health: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eIn terms of obesity and metabolic health, some studies used a genetic model of pituitary adenylate cyclase-activating polypeptide (PACAP)-deficient mice and found that the melanocortin receptor agonist Melanotan can partially rescue the impaired thermogenic capacity of PACAP-deficient mice during cold adaptation. This indicates that PACAP may play a role upstream of the melanocortin system, regulating the sympathetic nerve activity of brown adipose tissue in mice, thereby having an impact on obesity and metabolic health \u003csup\u003e[13]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eRegulation of metabolism and body temperature:\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eMelanotan also has a significant impact on the endocrine system. For example, intraperitoneal administration of Melanotan to mice can cause profound and transient hypometabolism\/hypothermia\u003csup\u003e[14]\u003c\/sup\u003e .Studies have shown that in mice lacking mast cells, the hypothermia caused by Melanotan is eliminated, suggesting that the participation of mast cells is required. Melanotan causes hypothermia in mice by activating mast cells and stimulating the histamine 1 receptor, and its mechanism of action involves the interaction of multiple endocrine factors and receptors.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eIn conclusion, as a synthetic substance that has attracted much attention, Melanotan exhibits unique characteristics in multiple fields. In the field of skin, by binding to specific receptors on melanocytes, it can effectively promote the production of melanin, providing a non-traditional tanning method for those who desire a healthy bronze complexion. Compared with tanning by prolonged exposure to ultraviolet rays, Melanotan can avoid the direct damage of ultraviolet rays to the skin and reduce the potential risks of sunburn, skin aging, and even skin cancer.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eFrom the perspective of sexual function regulation, Melanotan has a positive effect on stimulating spontaneous penile erection and enhancing sexual stimulation. This is a potential effective solution for some individuals with sexual dysfunction or those who hope to improve their sexual experience. It can achieve a positive impact on sexual function by activating specific neural pathways in the central and peripheral nervous systems and regulating related neurotransmitters and receptors, providing new possibilities for improving sexual health.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eIn the research on obesity and metabolic health, Melanotan also shows potential advantages. It may be able to regulate energy metabolism and body temperature and has a certain improvement effect on the impaired function of adipose tissue in obesity. It provides a new research direction for the treatment of obesity and the management of metabolic health, which is helpful for the development of new treatment strategies and the improvement of the health status of obese patients.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"prod_describe_new3\" id=\"prod_describe_new_3\"\u003e\n\u003cdiv class=\"prod_describe_new_content\"\u003e\n\u003cdiv class=\"prodDetail-editor-container sliderTable\"\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cstrong style=\"font-size: 24px;\"\u003eRelevant Citations\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[1] Langan E A, Nie Z, Rhodes L E. Melanotropic peptides: more than just 'Barbie drugs' and 'sun-tan jabs'?[J]. British Journal of Dermatology, 2010,163(3):451-455.DOI:10.1111\/j.1365-2133.2010.09891.x.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[2] Humphrey S M, Oo T, Barnetson S C. Clinical potential of Melanotan® (NDP-α-MSH) in skin protection -: current status and future perspective[J]. Experimental Dermatology, 2004,13(9):578.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[3] Perez-Bootello J, Cova-Martin R, Naharro-Rodriguez J, et al. Vitiligo: Pathogenesis and New and Emerging Treatments[J]. International Journal of Molecular Sciences, 2023,24(24).DOI:10.3390\/ijms242417306.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[4] Kim E S, Garnock-Jones K P. Afamelanotide: A Review in Erythropoietic Protoporphyria[J]. American Journal of Clinical Dermatology, 2016,17(2):179-185.DOI:10.1007\/s40257-016-0184-6.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[5] Minder A, Schneider-Yin X, Zulewski H, et al. Afamelanotide Is Associated with Dose-Dependent Protective Effect from Liver Damage Related to Erythropoietic Protoporphyria[J]. Life-Basel, 2023,13(4).DOI:10.3390\/life13041066.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[6] Dorr R T, Ertl G, Levine N, et al. Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers[J]. Archives of Dermatology, 2004,140(7):827-835.DOI:10.1001\/archderm.140.7.827.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[7] Reid C, Fitzgerald T, Fabre A, et al. Atypical melanocytic naevi following melanotan injection.[J]. Irish Medical Journal, 2013,106(5):148-149. https:\/\/pubmed.ncbi.nlm.nih.gov\/23914578\/\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[8] Dominguez-Mozo M I, Toledano-Martinez E, Rodriguez-Rodriguez L, et al. JC virus reactivation in patients with autoimmune rheumatic diseases treated with rituximab[J]. Scandinavian Journal of Rheumatology, 2016,45(6):507-511.DOI:10.3109\/03009742.2015.1135980.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[9] Wu V, Sykes E A, Beyea M M, et al. Approche à adopter pour la prise en charge de la maladie de Ménière. Canadian Family Physician Medecin De Famille Canadien, 2019,65(7):468-472. https:\/\/pubmed.ncbi.nlm.nih.gov\/31300427\/\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e[10] McNeil M M, Nahhas A F, Braunberger T L, et al. Afamelanotide in the Treatment of Dermatologic Disease[J]. Skin Therapy Letter, 2018,23(6):6-10. https:\/\/pubmed.ncbi.nlm.nih.gov\/30517779\/\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp data-start=\"293\" data-end=\"654\"\u003e\u003cstrong\u003eFor Research Use Only\u003c\/strong\u003e\u003cbr data-start=\"321\" data-end=\"324\"\u003eThis compound is provided exclusively for in vitro laboratory research. It is not intended for human or animal consumption, diagnosis, treatment, or medical use. Not for dietary, cosmetic, or veterinary purposes. This product has not been evaluated by the U.S. Food and Drug Administration or any other regulatory authority.\u003c\/p\u003e\n\u003chr data-start=\"656\" data-end=\"659\"\u003e\n\u003cp data-start=\"661\" data-end=\"910\"\u003e\u003cstrong\u003eDisclaimer\u003c\/strong\u003e\u003cbr data-start=\"675\" data-end=\"678\"\u003eAll information is for educational purposes only. Humatide makes no claims regarding efficacy or safety. Purchasers are responsible for ensuring proper handling and use in compliance with all applicable laws and regulations.\u003c\/p\u003e\n\u003chr data-start=\"912\" data-end=\"915\"\u003e\n\u003cp data-start=\"917\" data-end=\"1259\"\u003e\u003cstrong\u003eTerms of Sale\u003c\/strong\u003e\u003cbr data-start=\"934\" data-end=\"937\"\u003eBy purchasing from Humatide, you confirm that you are a qualified researcher with the knowledge and facilities to safely handle and store research chemicals. All sales are final. Humatide assumes no liability for misuse, misrepresentation, or unintended consequences arising from the use of this product.\u003c\/p\u003e","brand":"Humatide","offers":[{"title":"10MG","offer_id":46385033281726,"sku":null,"price":25.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0748\/8667\/6670\/files\/Melanotan2.jpg?v=1781292927","url":"https:\/\/shop.humatide.com\/products\/melanotan-2","provider":"Humatide","version":"1.0","type":"link"}