{"product_id":"aicar","title":"AICAR","description":"\u003ch2\u003e\u003cstrong\u003eAICAR Description\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003eAICAR is an analogue of adenosine monophosphate, which is a natural molecule, while the peptide itself can be synthesized in the laboratory. Its main function is the activation of AMP-activated protein kinase (AMPK) in adipocytes (fat cells), hepatocytes (liver cells), skeletal muscle, and many other tissues. Activation of this enzyme achieves various effects and potential beneficial properties. One of them is the regulation of glucose and lipid metabolism and the inhibition of various pro-inflammatory cytokines.\u003c\/p\u003e\n\u003cp\u003eIn addition to acting as a metabolic regulator, it can also inhibit anabolic processes. Another crucial effect is reflected in the promotion of differentiation of mesenchymal stem cells into active cell forms, as well as the inhibition of certain enzymes (acetyl-CoA carboxylase, malonyl-CoA) and the increase in fatty acid oxidation and glucose uptake. Due to these properties that the peptide exerts on the body, AICAR is considered a potential part of therapy for diabetes type 2 (by increasing the metabolic activity of tissues). It can also be used to protect against cardiac ischemia that occurs after a heart attack or in cases of heart failure. The peptide also has antioxidant properties that are crucial to potentially slowing down the physiological signs of aging. Numerous studies are underway on the use of this compound in many autoimmune diseases, cancers, and other inflammatory conditions.\u003c\/p\u003e\n\u003ch3 class=\"text-lg font-bold text-text-100 mt-1 -mb-1.5\"\u003ePeptide Information\u003c\/h3\u003e\n\u003ctable class=\"bg-bg-100 min-w-full border-separate border-spacing-0 text-sm leading-[1.88888] whitespace-normal\" style=\"width: 100%; height: 138.867px;\"\u003e\n\u003cthead class=\"border-b-border-100\/50 border-b-[0.5px] text-left\"\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003cth class=\"text-text-000 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003eProperty\u003c\/th\u003e\n\u003cth class=\"text-text-000 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003eValue\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003ePeptide Sequence\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003eThr-Lys-Pro-Arg-Pro-Gly-Pro\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 21.2667px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 21.2667px;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 21.2667px;\"\u003e\n\u003cspan\u003eC\u003csub\u003e9\u003c\/sub\u003eH\u003csub\u003e15\u003c\/sub\u003eN\u003csub\u003e4\u003c\/sub\u003eO\u003csub\u003e8\u003c\/sub\u003eP\u003c\/span\u003e\u003csub\u003e\u003c\/sub\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003e338.21 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003e3031-94-5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003e65110\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"[tbody\u0026gt;\u0026amp;]:odd:bg-bg-500\/10\" style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 24.3943%; height: 19.6px;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd class=\"border-t-border-100\/50 [\u0026amp;:not(:first-child)]:-x-[hsla(var(--border-100) \/ 0.5)] border-t-[0.5px] px-2 [\u0026amp;:not(:first-child)]:border-l-[0.5px]\" style=\"width: 72.8231%; height: 19.6px;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eAICA ribonucleotide, Z-nucleotide\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3\u003eAICAR and Cardioprotective Effect\u003c\/h3\u003e\n\u003cp\u003eThe cardioprotective effect is extremely beneficial, and since there were scientific assumptions that AICAR had such a property, studies were conducted to determine this.\u003c\/p\u003e\n\u003cp\u003eOne of the many studies used a molecule known as doxorubicin (DOX). This powerful chemotherapeutic agent causes serious cardiotoxic effects and dangers to the cardiovascular system that can lead to heart failure. DOX was used to cause heart damage and induce a state of heart failure in the rats used for this study, and then the animals were treated with AICAR. Adenosine monophosphate-dependent kinase (AMPK) regulates mitochondrial biogenesis (and thus energy metabolism) and enhances fatty acid oxidation. Scientists hypothesized that impaired mitochondrial function could be crucial to the cardiotoxic effect caused by DOX, so they attempted to restore mitochondrial function by activating AMPK, which led to a cardioprotective effect. Since the main function of AICAR is to activate this enzyme, the peptide could lead to an improvement in the case of heart failure.\u003c\/p\u003e\n\u003cp\u003eThe results of the study showed that AICAR could improve cardiac systolic function and cardiac mitochondrial fatty acid oxidation. A key potential effect of this peptide is preventing myocardial mass loss. In rats treated with DOX, pathways related to protein synthesis were disrupted, and after treatment with this peptide, they were normalized.\u003c\/p\u003e\n\u003cp\u003eThis treatment also prevented dyslipidemia and excessive body weight loss, which may be crucial in preserving myocardial mass. Therefore, AICAR can potentially be used as a cardioprotective agent in heart failure to preserve cardiac function and mass.\u003c\/p\u003e\n\u003ch3\u003ePotential Therapy for Type 2 Diabetes\u003c\/h3\u003e\n\u003cp\u003eType 2 diabetes is a disease of glucose metabolism in which insulin receptors become resistant to insulin, leading to elevated blood sugar levels. Treatment options primarily include diet and sometimes drug therapy. This study aimed to examine the effect of AICAR, whose main function is the activation of AMPK, and its effect on metabolic syndrome and type 2 diabetes. This condition was induced by a high-fat diet in the mice model used for the study. The parameters monitored were body weight, glucose, and insulin levels. Internal organs and visceral fat were also assessed.\u003c\/p\u003e\n\u003cp\u003eAll animals showed signs of metabolic syndrome or type 2 diabetes, weight gain, hyperglycemia, hyperinsulinemia, increased abdominal fat volume, and changes in internal organs. Treatment with AICAR resulted in a reduction in body weight, abdominal fat mass, and improved visceral image. Inflammation in adipose tissue results from insulin resistance, and AICAR can reduce tissue inflammation and thus improve insulin receptor sensitivity. As a result of this mechanism of action, blood sugar homeostasis could be normalized. This peptide has shown potential therapeutic effects in the treatment of metabolic syndrome and type 2 diabetes.\u003c\/p\u003e\n\u003ch3\u003eAnti-Inflammatory Properties\u003c\/h3\u003e\n\u003cp\u003eThe anti-inflammatory effect is helpful because it can be used for any condition that has an inflammatory process as its cause. Scientists have studied the effect of this peptide on various conditions, one of which was chronic pain, and inflammation can often be the cause. Scientists assumed that the activation of AMPK could alleviate the intensity of pain, and knowing that AICAR is the main activator of this enzyme, they monitored the therapeutic effect of the peptide on this condition. The assumption was that the mechanism of action could be achieved by inhibiting pro-inflammatory cytokines (interleukin-1β). The immune response in experimental animals is easily induced by complete Freund's adjuvant (CFA). This molecule is a driver of pathological changes and causes inflammatory pain. Four days after pain induction and the application of AICAR, the main parameters (most reflect the intensity of pain) were measured.\u003c\/p\u003e\n\u003cp\u003eIn the results, peptides showed analgesic effects and reduced pain intensity by inhibiting pro-inflammatory cytokines. Scientists assume that due to the reduction of interleukin-1β expression and, in general, the activation of AMPK, this amino acid sequence may have a potential therapeutic effect on chronic inflammatory pain.\u003c\/p\u003e\n\u003ch3\u003eCancer Research\u003c\/h3\u003e\n\u003cp\u003eAMPK is believed to have many effects on reducing the amount of cancer cells and tumor survival rates. Scientists assume that by activating this enzyme, tumor cells that are exposed to this environment will start to die over time, slowing down their metabolism. AICAR (as the main activator of this enzyme) can be used together with other chemotherapy drugs to further enhance its effect.\u003c\/p\u003e\n\u003cp\u003eThe results of studies on rat models have shown that the peptide can potentially reduce the dosage of other chemotherapeutic drugs, reduce their side effects, and also act on tumors that are not recommended for chemotherapy.\u003c\/p\u003e\n\u003cp data-start=\"293\" data-end=\"654\"\u003e\u003cstrong\u003eFor Research Use Only\u003c\/strong\u003e\u003cbr data-start=\"321\" data-end=\"324\"\u003eThis compound is provided exclusively for in vitro laboratory research. It is not intended for human or animal consumption, diagnosis, treatment, or medical use. Not for dietary, cosmetic, or veterinary purposes. This product has not been evaluated by the U.S. Food and Drug Administration or any other regulatory authority.\u003c\/p\u003e\n\u003chr data-start=\"656\" data-end=\"659\"\u003e\n\u003cp data-start=\"661\" data-end=\"910\"\u003e\u003cstrong\u003eDisclaimer\u003c\/strong\u003e\u003cbr data-start=\"675\" data-end=\"678\"\u003eAll information is for educational purposes only. Humatide makes no claims regarding efficacy or safety. Purchasers are responsible for ensuring proper handling and use in compliance with all applicable laws and regulations.\u003c\/p\u003e\n\u003chr data-start=\"912\" data-end=\"915\"\u003e\n\u003cp data-start=\"917\" data-end=\"1259\"\u003e\u003cstrong\u003eTerms of Sale\u003c\/strong\u003e\u003cbr data-start=\"934\" data-end=\"937\"\u003eBy purchasing from Humatide, you confirm that you are a qualified researcher with the knowledge and facilities to safely handle and store research chemicals. All sales are final. Humatide assumes no liability for misuse, misrepresentation, or unintended consequences arising from the use of this product.\u003c\/p\u003e","brand":"Humatide","offers":[{"title":"50MG","offer_id":46016056590526,"sku":null,"price":30.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0748\/8667\/6670\/files\/AICAR.jpg?v=1781293914","url":"https:\/\/shop.humatide.com\/products\/aicar","provider":"Humatide","version":"1.0","type":"link"}